Construction of optically active CF3-containing quaternary carbon centers via stereospecific SN2′ reaction

被引：63

作者：

Kimura, M

Yamazaki, T

Kitazume, T

Kubota, T

机构：

[1] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[2] Ibaraki Univ, Dept Mat Sci, Hitachi, Ibaraki 3168511, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 25期

关键词：

D O I：

10.1021/ol0481941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphates from 3-substituted 4,4,4-trifluorobut-2-en-1-ols were found to be effective for construction of CF3-containing quaternary carbon centers by way of Cu(l)-catalyzed Grignard reactions in the presence of catalytic amounts of CuCN and trimethylsilyl chloride (TMSCI) in an anti S(N)2' manner.

引用

页码：4651 / 4654

页数：4

共 29 条

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[2]

BACKVALL JE, 1990, J AM CHEM SOC, V112, P6615

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