Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

被引：1
作者：
Yoon, Seong Shoon [1 ]
Yun, Jaesuk [2 ,3 ]
Lee, Bong Hyo [4 ]
Kim, Hee Young [1 ]
Yang, Chae Ha [1 ]
机构：
[1] Daegu Haany Univ, Coll Korean Med, Dept Physiol, Daegu 42158, South Korea
[2] Chungbuk Natl Univ, Coll Pharm, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea
[3] Chungbuk Natl Univ, Med Res Ctr, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea
[4] Daegu Haany Univ, Coll Korean Med, Dept Acupuncture Moxibust & Acupoint, Daegu 42158, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 14期
基金：
新加坡国家研究基金会;
关键词：
acupuncture; intracranial self-stimulation; rats; medial forebrain bundle; cocaine; brain reward function; VENTRAL TEGMENTAL AREA; BRAIN-STIMULATION; NUCLEUS-ACCUMBENS; DOPAMINE; COCAINE; RECEPTORS; RELEASE;
D O I：
10.3390/ijms22147519
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naive rats.
引用
收藏
页数：10
相关论文
共 50 条
[41]   Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans [J].
Panther, Patricia ;
Kuehne, Maria ;
Voges, Juergen ;
Nullmeier, Sven ;
Kaufmann, Joern ;
Hausmann, Janet ;
Bittner, Daniel ;
Galazky, Imke ;
Heinze, Hans-Jochen ;
Kupsch, Andreas ;
Zaehle, Tino .
BMC NEUROSCIENCE, 2019, 20 (1)
[42]   COCAINE ENHANCES THE REWARD VALUE OF MEDIAL PREFRONTAL CORTEX SELF-STIMULATION [J].
CORBETT, D .
NEUROREPORT, 1991, 2 (12) :805-808
[43]   ACTIONS AND INTERACTIONS OF COCAINE ON SELF-STIMULATION BEHAVIOR IN RATS [J].
AULAKH, CS ;
GHOSH, B ;
PRADHAN, SN .
PSYCHOPHARMACOLOGY, 1979, 63 (01) :75-79
[44]   Desynchronization of Theta Oscillations in Prefrontal Cortex during Self-stimulation of the Medial Forebrain Bundles in Mice [J].
Hwang, Eunjin ;
Lee, Heonsoo ;
Choi, Jee Hyun .
EXPERIMENTAL NEUROBIOLOGY, 2018, 27 (03) :181-188
[45]   Interactions between pain states and opioid reward assessed with intracranial self-stimulation in rats [J].
Moerke, Megan J. ;
Negus, S. Stevens .
NEUROPHARMACOLOGY, 2019, 160
[46]   Intracranial self-stimulation in FAST and SLOW mice: effects of alcohol and cocaine [J].
Fish, Eric W. ;
Robinson, J. Elliott ;
Krouse, Michael C. ;
Hodge, Clyde W. ;
Reed, Cheryl ;
Phillips, Tamara J. ;
Malanga, C. J. .
PSYCHOPHARMACOLOGY, 2012, 220 (04) :719-730
[47]   Potentiation of intracranial self-stimulation during prolonged subcutaneous infusion of cocaine [J].
Hernandez, Giovanni ;
Haines, Eric ;
Shizgal, Peter .
JOURNAL OF NEUROSCIENCE METHODS, 2008, 175 (01) :79-87
[48]   Role of 5-HT2C receptors in effects of monoamine releasers on intracranial self-stimulation in rats [J].
Clayton T. Bauer ;
Matthew L. Banks ;
Bruce E. Blough ;
S. Stevens Negus .
Psychopharmacology, 2015, 232 :3249-3258
[49]   Effects of the Synthetic Cathinone α-Pyrrolidinobutiothiophenone (α-PBT) on Discriminative Stimulus Effects and Intracranial Self-Stimulation Thresholds in Male Rats [J].
Jang, Eun Young ;
Lee, Bong Hyo ;
Yun, Jaesuk ;
Yang, Chae Ha ;
Yoon, Seong Shoon .
ACS CHEMICAL NEUROSCIENCE, 2024, 15 (12) :2420-2431
[50]   BROMOCRIPTINE REVERSES THE ELEVATION IN INTRACRANIAL SELF-STIMULATION THRESHOLDS OBSERVED IN A RAT MODEL OF COCAINE WITHDRAWAL [J].
MARKOU, A ;
KOOB, GF .
NEUROPSYCHOPHARMACOLOGY, 1992, 7 (03) :213-224
12345