Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

被引：1

作者：

Yoon, Seong Shoon ^{[1
]}

Yun, Jaesuk ^{[2
,3
]}

Lee, Bong Hyo ^{[4
]}

Kim, Hee Young ^{[1
]}

Yang, Chae Ha ^{[1
]}

机构：

[1] Daegu Haany Univ, Coll Korean Med, Dept Physiol, Daegu 42158, South Korea

[2] Chungbuk Natl Univ, Coll Pharm, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea

[3] Chungbuk Natl Univ, Med Res Ctr, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea

[4] Daegu Haany Univ, Coll Korean Med, Dept Acupuncture Moxibust & Acupoint, Daegu 42158, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

acupuncture; intracranial self-stimulation; rats; medial forebrain bundle; cocaine; brain reward function; VENTRAL TEGMENTAL AREA; BRAIN-STIMULATION; NUCLEUS-ACCUMBENS; DOPAMINE; COCAINE; RECEPTORS; RELEASE;

D O I：

10.3390/ijms22147519

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naive rats.

引用

页数：10

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