Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

被引：1
|
作者：
Yoon, Seong Shoon [1 ]
Yun, Jaesuk [2 ,3 ]
Lee, Bong Hyo [4 ]
Kim, Hee Young [1 ]
Yang, Chae Ha [1 ]
机构：
[1] Daegu Haany Univ, Coll Korean Med, Dept Physiol, Daegu 42158, South Korea
[2] Chungbuk Natl Univ, Coll Pharm, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea
[3] Chungbuk Natl Univ, Med Res Ctr, Osongsaengmyeong 1 Ro, Cheongju 28160, Chungbuk, South Korea
[4] Daegu Haany Univ, Coll Korean Med, Dept Acupuncture Moxibust & Acupoint, Daegu 42158, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 14期
基金：
新加坡国家研究基金会;
关键词：
acupuncture; intracranial self-stimulation; rats; medial forebrain bundle; cocaine; brain reward function; VENTRAL TEGMENTAL AREA; BRAIN-STIMULATION; NUCLEUS-ACCUMBENS; DOPAMINE; COCAINE; RECEPTORS; RELEASE;
D O I：
10.3390/ijms22147519
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naive rats.
引用
收藏
页数：10
相关论文
共 50 条
12345