Synthesis and molecular structure of 6-aryl-3-ethoxycarbonyl-4-hydroxypyridazines

被引：6

作者：

Aliev, ZG ^{[1
]}

Vyaznikova, NG

Zalesov, VV

Kataev, SS

Andreichikov, YS

Atovmyan, LO

机构：

[1] Russian Acad Sci, Inst Chem Phys, Chernogolovka 142432, Moscow Region, Russia

[2] Pharmaceut Acad, Perm 614000, Russia

[3] Perm State Univ, Perm 614600, Russia

[4] Russian Acad Sci, Inst Tech Chem, Ural Branch, Perm 614600, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 1997年 / 46卷 / 12期

关键词：

diazo compounds; substituted pyridazines; acylation; molecular and crystal structure;

D O I：

10.1007/BF02495271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ethyl Z-5-aryl-2-diazo-5-hydroxy-3-oxopent-4-enoates interact with triphenylphosphine to give 6-aryl-3-ethoxycarbonyl-4-hydroxypyridazines (Ar = Ph, 4-MeC6H4, 4-ClC6H4). Quantum-chemical calculations (MNDO) were performed to estimate the tautomeric equilibrium in the latter using a 6-phenyl-substituted derivative as an example. Acetylation of the 4-hydroxypyridazines led to 4-acetoxy-6-aryl-3-ethoxycarbonylpyridazines. The structure of the latter was confirmed by an X-ray diffraction analysis of 4-acetoxy-3-ethoxycarbonyl-6-(p-tolyl)pyridazine.

引用

页码：2142 / 2145

页数：4