The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs

被引：48
作者：
Wang, Yen-Jen [1 ]
Larsson, Mikael [2 ]
Huang, Wei-Ting [1 ]
Chiou, Shih-Hwa [3 ,4 ]
Nicholls, Stephen J. [5 ]
Chao, Jui-I [6 ]
Liu, Dean-Mo [1 ]
机构：
[1] Natl Chiao Tung Univ, BioICT Consortium, Dept Mat Sci & Engn, Nanobioengn Lab, Hsinchu 301, Taiwan
[2] Univ S Australia, Future Ind Inst, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia
[3] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan
[4] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan
[5] Univ Adelaide, South Australian Hlth & Med Res Inst, Adelaide, SA 5001, Australia
[6] Natl Chiao Tung Univ, BioICT Consortium, Dept & Inst Biol Sci & Technol, Hsinchu 300, Taiwan
来源：
PROGRESS IN POLYMER SCIENCE | 2016年 / 57卷
关键词：
Cardiovascular diseases; Drug delivery; Nanoparticles; Nanostructured; Polymers; Theranostic; DRUG-ELUTING STENTS; SMOOTH-MUSCLE-CELLS; LOW-DENSITY-LIPOPROTEIN; BLOOD-BRAIN-BARRIER; BARE METAL STENTS; IN-VIVO; LOCAL-DELIVERY; BIODEGRADABLE NANOPARTICLES; GENE DELIVERY; NEOINTIMAL HYPERPLASIA;
D O I：
10.1016/j.progpolymsci.2016.01.002
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the ossibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy. (c) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：153 / 178
页数：26
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