Protective effect of methanol extract of Uncaria rhynchophylla against excitotoxicity induced by N-methyl-D-aspartate in rat hippocampus

被引：0
|
作者：
Lee, J
Son, D
Lee, P
Kim, DK
Shin, MC
Jang, MH
Kim, CJ
Kim, YS
Kim, SY
Kim, H
机构：
[1] Kyung Hee Univ, Grad Sch E W Med Sci, Dept Herbal Pharmacol, Dongdaemun Ku, Seoul 130701, South Korea
[2] Woosuk Univ, Coll Pharm, Dept Herbal Pharmacol, Chonju, South Korea
[3] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Pharmacol, Seoul, South Korea
[5] Med Res Ctr, Neurosci Res Inst, Seoul, South Korea
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2003年 / 92卷 / 01期
关键词：
Uncaria rhynchophylla; N-methyl-D-aspartate; hippocampus;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Uncaria rhynchophylla is a medicinal herb used for convulsive disorders in Oriental medicine. In this study, the effect of the methanol extract of Uncaria rhynchophylla against N-methyl-D-aspartate (NMDA)-induced excitotoxicity was investigated. Pretreatment with the extract of Uncaria rhynchopylla reduced the degree of neuronal damage induced by NMDA exposure in cultured hippocampal slices. In the patch clamp study, Uncaria rhynchophylla significantly inhibited NMDA receptor-activated ion current in acutely dissociated hippocampal CA1 neurons. These results indicate that Uncaria rhynchophylla offers protection against NMDA-induced neuronal injury and inhibitory action on NMDA receptor-mediated ion current may be a mechanism behind the neuroprotective effect of Uncaria rhynchophylla.
引用
收藏
页码：70 / 73
页数：4
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