ExoCarta: A Web-Based Compendium of Exosomal Cargo

被引：1048

作者：

Keerthikumar, Shivakumar ^{[1
]}

Chisanga, David ^{[2
]}

Ariyaratne, Dinuka ^{[1
]}

Al Saffar, Haidar ^{[1
]}

Anand, Sushma ^{[1
]}

Zhao, Kening ^{[1
]}

Samuel, Monisha ^{[3
]}

Pathan, Mohashin ^{[1
]}

Jois, Markandeya ^{[3
]}

Chilamkurti, Naveen ^{[2
]}

Gangoda, Lahiru ^{[1
]}

Mathivanan, Suresh ^{[1
]}

机构：

[1] La Trobe Univ, La Trobe Inst Mol Sci, Dept Biochem & Genet, Melbourne, Vic 3086, Australia

[2] La Trobe Univ, Dept Comp Sci & Informat Technol, Melbourne, Vic 3086, Australia

[3] La Trobe Univ, Sch Life Sci, Dept Physiol Anat & Microbiol, Melbourne, Vic 3086, Australia

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2016年 / 428卷 / 04期

基金：

美国国家卫生研究院; 澳大利亚研究理事会;

关键词：

exosomes; FunRich; extracellular vesicles; protein-protein interactions; EXTRACELLULAR VESICLES; PROTEINS; DATABASE; REVEALS;

D O I：

10.1016/j.jmb.2015.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated Web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (>54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, >7540 RNA and 1116 lipid molecules from more than 286 exosomal studies annotated with International Society for Extracellular Vesicles minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich (http://www.funrich.org) tool for additional functional enrichment and interaction network analysis. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：688 / 692

页数：5

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