Efficient synthesis of conjugated alkynyl cycloalkenones: Pd(PPh3)4-AgOAc-catalyzed direct coupling of 1-alkynes with 3-oxocycloalkenyl triflates

被引：9

作者：

Jiang, Chenggang ^{[1
]}

Zhang, Zonglei ^{[1
]}

Xu, Hangxian ^{[1
]}

Sun, Liang ^{[1
]}

Liu, Lanhai ^{[1
]}

Wang, Cunde ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2010年 / 24卷 / 03期

关键词：

conjugated alkynyl cycloalkenones; 3-oxocycloalkenyl triflates; palladium(0) catalyst; silver acetate; Sonogashira-Linstrumelle reaction; STILLE TANDEM REACTION; STEREOSELECTIVE-SYNTHESIS; ANTITUMOR ANTIBIOTICS; TERMINAL ACETYLENES; BIOACTIVE ANALOGS; SILVER SALTS; ONE-POT; CHEMISTRY; ENEDIYNE; ENYNES;

D O I：

10.1002/aoc.1592

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Palladium-silver acetate-catalyzed cross coupling of vinyl triflates and 1-alkynes was investigated. This strategy offered a very straightforward and efficient method for access to conjugated alkynyl cycloalkenones from the conjugated vinyl triflates and 1-alkynes. Moreover, the triflates derived from 1,3-cycloalkadione needed no further purification and could be reacted immediately with 1-alkynes to provide the conjugated alkynyl cycloalkenanes in excellent overall yields. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：208 / 214

页数：7

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