Management of Immunosuppression in Liver Transplantation

被引：24

作者：

Dhanasekaran, Renumathy ^{[1
]}

机构：

[1] Stanford Univ, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USA

来源：

CLINICS IN LIVER DISEASE | 2017年 / 21卷 / 02期

关键词：

Transplantation; Rejection; Calcineurin; Immunosuppression; Hepatitis C; ANTIBODY-MEDIATED REJECTION; RABBIT ANTITHYMOCYTE GLOBULIN; RANDOMIZED CONTROLLED-TRIAL; SIROLIMUS-BASED IMMUNOSUPPRESSION; BASILIXIMAB INDUCTION THERAPY; SOLID-ORGAN TRANSPLANTATION; CHRONIC HEPATITIS-C; MYCOPHENOLATE-MOFETIL; RENAL-FUNCTION; CALCINEURIN INHIBITOR;

D O I：

10.1016/j.cld.2016.12.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver transplantation outcomes have significantly improved over the past few decades owing largely to the introduction of effective immunosuppression medications. Further comprehension of the unique immune microenvironment of the liver has led to the development of newer molecular targeted therapeutics. Understanding the mechanism of action and adverse effect profiles of these medications is crucial for appropriate management of posttransplant patients. In this review, the author describes the immunologic response elicited by liver transplantation, chronicles the various immunosuppressant drug classes, discusses the evidence behind their use, and evaluates the management of special subpopulations of posttransplantation patients.

引用

页码：337 / +

页数：18

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