Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology

被引：104
作者：
Bilyk, Olena [1 ]
Coatham, Mackenzie [2 ]
Jewer, Michael [1 ,3 ]
Postovit, Lynne-Marie [1 ]
机构：
[1] Univ Alberta, Dept Oncol, Edmonton, AB, Canada
[2] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB, Canada
[3] Western Univ, Dept Anat & Cell Biol, London, ON, Canada
来源：
FRONTIERS IN ONCOLOGY | 2017年 / 7卷
基金：
加拿大健康研究院;
关键词：
epithelial-to-mesenchymal transition; adenomyosis; endometriosis; ovarian cancer; endometrial cancer; tumor microenvironment; OVARIAN-CANCER CELLS; NECROSIS-FACTOR-ALPHA; CIRCULATING TUMOR-CELLS; GRADE SEROUS OVARIAN; FOLLICLE-STIMULATING-HORMONE; INDUCIBLE FACTOR 1-ALPHA; ENDOMETRIAL CANCER; E-CADHERIN; TGF-BETA; FALLOPIAN-TUBE;
D O I：
10.3389/fonc.2017.00145
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis.
引用
收藏
页数：21
相关论文
共 259 条
[41]   EGF-Induced EMT and Invasiveness in Serous Borderline Ovarian Tumor Cells: A Possible Step in the Transition to Low-Grade Serous Carcinoma Cells? [J].
Cheng, Jung-Chien ;
Auersperg, Nelly ;
Leung, Peter C. K. .
PLOS ONE, 2012, 7 (03)
[42]   The essential roles of CCR7 in epithelial-to-mesenchymal transition induced by hypoxia in epithelial ovarian carcinomas [J].
Cheng, Shaomei ;
Han, Lin ;
Guo, Jingyan ;
Yang, Qing ;
Zhou, Jianfang ;
Yang, Xiangshan .
TUMOR BIOLOGY, 2014, 35 (12) :12293-12298
[43]   High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability [J].
Cheung, Lydia W. T. ;
Hennessy, Bryan T. ;
Li, Jie ;
Yu, Shuangxing ;
Myers, Andrea P. ;
Djordjevic, Bojana ;
Lu, Yiling ;
Stemke-Hale, Katherine ;
Dyer, Mary D. ;
Zhang, Fan ;
Ju, Zhenlin ;
Cantley, Lewis C. ;
Scherer, Steven E. ;
Liang, Han ;
Lu, Karen H. ;
Broaddus, Russell R. ;
Mills, Gordon B. .
CANCER DISCOVERY, 2011, 1 (02) :170-185
[44]   Epithelial-to-Mesenchymal Transition in Granulosa Cells: A Key to Activation of Follicle Growth? [J].
Childs, Andrew J. ;
McNeilly, Alan S. .
BIOLOGY OF REPRODUCTION, 2012, 86 (05)
[45]   ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas [J].
Colas, E. ;
Muinelo-Romay, L. ;
Alonso-Alconada, L. ;
Llaurado, M. ;
Monge, M. ;
Barbazan, J. ;
Gonzalez, M. ;
Schoumacher, M. ;
Pedrola, N. ;
Ertekin, T. ;
Devis, L. ;
Ruiz, A. ;
Castellvi, J. ;
Doll, A. ;
Gil-Moreno, A. ;
Vazquez-Levin, M. ;
Lapyckyj, L. ;
Lopez-Lopez, R. ;
Robine, S. ;
Friederich, E. ;
Castro, M. ;
Reventos, J. ;
Vignjevic, D. ;
Abal, M. .
ONCOGENE, 2012, 31 (45) :4778-4788
[46]   Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas [J].
Colomiere, M. ;
Ward, A. C. ;
Riley, C. ;
Trenerry, M. K. ;
Cameron-Smith, D. ;
Findlay, J. ;
Ackland, L. ;
Ahmed, N. .
BRITISH JOURNAL OF CANCER, 2009, 100 (01) :134-144
[47]   Epidermal growth factor-induced ovarian carcinoma cell migration is associated with JAK2/STAT3 signals and changes in the abundance and localization of α6β1 integrin [J].
Colomiere, Michelle ;
Findlay, Jock ;
Ackland, Leigh ;
Ahmed, Nuzhat .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (05) :1034-1045
[48]   Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation [J].
Cousins, Fiona L. ;
Murray, Alison ;
Esnal, Arantza ;
Gibson, Douglas A. ;
Critchley, Hilary O. D. ;
Saunders, Philippa T. K. .
PLOS ONE, 2014, 9 (01)
[49]  
Creasman W T, 2001, J Epidemiol Biostat, V6, P47
[50]   The endocrinology of menstruation - a role for the immune system [J].
Critchley, HOD ;
Kelly, RW ;
Brenner, RM ;
Baird, DT .
CLINICAL ENDOCRINOLOGY, 2001, 55 (06) :701-710
12345678910