Epithelial-to-Mesenchymal Transition in the Female Reproductive Tract: From Normal Functioning to Disease Pathology

被引：104

作者：

Bilyk, Olena ^{[1
]}

Coatham, Mackenzie ^{[2
]}

Jewer, Michael ^{[1
,3
]}

Postovit, Lynne-Marie ^{[1
]}

机构：

[1] Univ Alberta, Dept Oncol, Edmonton, AB, Canada

[2] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB, Canada

[3] Western Univ, Dept Anat & Cell Biol, London, ON, Canada

来源：

FRONTIERS IN ONCOLOGY | 2017年 / 7卷

基金：

加拿大健康研究院;

关键词：

epithelial-to-mesenchymal transition; adenomyosis; endometriosis; ovarian cancer; endometrial cancer; tumor microenvironment; OVARIAN-CANCER CELLS; NECROSIS-FACTOR-ALPHA; CIRCULATING TUMOR-CELLS; GRADE SEROUS OVARIAN; FOLLICLE-STIMULATING-HORMONE; INDUCIBLE FACTOR 1-ALPHA; ENDOMETRIAL CANCER; E-CADHERIN; TGF-BETA; FALLOPIAN-TUBE;

D O I：

10.3389/fonc.2017.00145

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis. We also summarize the current literature relating to EMT in the context of ovarian and endometrial carcinomas, with a particular focus on how molecular mechanisms and the tumor microenvironment can govern cancer cell plasticity, therapy resistance, and metastasis.

引用

页数：21

共 259 条

[1] Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden [J].