The Role of Non-coding RNAs in Oncology

被引：1215

作者：

Slack, Frank J. ^{[1
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Chinnaiyan, Arul M. ^{[4
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机构：

[1] Harvard Med Sch, Initiat RNA Med, Boston, MA 02215 USA

[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[3] Harvard Med Sch, Dept Med, Boston, MA 02215 USA

[4] Univ Michigan, Michigan Ctr Translat Pathol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

CELL | 2019年 / 179卷 / 05期

关键词：

PROSTATE-CANCER; PROGNOSTIC BIOMARKER; CIRCULAR RNA; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; BREAST-CANCER; METASTATIC PROGRESSION; REGULATORY NETWORK; ONCOGENIC ACTIVITY; ONCOMIR ADDICTION;

D O I：

10.1016/j.cell.2019.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. An explosion of studies into ncRNA biology has since shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner. As a result, hundreds of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun and these are likely just the beginning.

引用

页码：1033 / 1055

页数：23

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