Usefulness of serum interleukin-33 as a prognostic marker of severe traumatic brain injury

被引:21
作者
Zhang, Zu-Yong [1 ]
Li, Jun [1 ]
Ye, Qi [1 ]
Dong, Yong [1 ]
Bao, Guang-Ming [1 ]
Shen, You-Kui [1 ]
Weng, Jian-Feng [2 ]
Luo, Li-Feng [2 ]
Cen, Meng [2 ]
机构
[1] Zhejiang Chinese Med Univ, Guangxing Hosp, Hangzhou Hosp Tradit Chinese Med, Dept Neurosurg, 453 Tiyuchang Rd, Hangzhou 310007, Zhejiang, Peoples R China
[2] CHC Int Hosp, Dept Neurosurg, 599 Shiji Ave, Cixi 315315, Peoples R China
关键词
Traumatic brain injury; Interleukin-33; Prognosis; Severity; Inflammation; IL-33; COAGULOPATHY; PROGRESSION; BIOMARKERS; CONTUSION; OUTCOMES; STROKE; CT;
D O I
10.1016/j.cca.2019.07.008
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Interleukin-33 is recently identified as a brain injury biomarker. We determined whether serum interlerukin-33 concentrations are associated with inflammation, severity and prognosis after traumatic brain injury (TBI). Methods: We detected serum interlerukin-33 concentrations of 102 healthy controls and 102 severe TBI patients, as well as serum concentrations of 3 inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha and C-reactive protein) and 7 cell-specific proteins (myelin basic protein, glial fibrillary astrocyte protein, S100B, neuron-specific enolase, phosphorylated axonal neurofilament subunit H, Tau and ubiquitin carboxyl-terminal hydrolase L1) in 102 severe TBI patients. The recorded poor prognosis variables included acute lung injury, acute traumatic coagulopathy, progressive hemorrhagic injury, posttraumatic cerebral infarction and six-month mortality and poor outcome (Glasgow score of 1-3). Results: Median interlerukin-33 concentration of patients (692 pg/mL) was substantially raised, as compared to controls. Interlerukin-33 concentrations were significantly correlated with Glasgow coma scale (GCS) score and the preceding biomarkers concentrations. Interlerukin-33 concentration > 692 pg/mL emerged as an independent prognostic predictor and its discriminatory capability exceeded those of the above-mentioned inflammatory biomarkers concentrations and was in the range of GCS scores and the aforementioned cell-specific proteins concentrations. Conclusion: Ascending serum interlerukin-33 concentrations could reflect inflammation, severity and worse prognosis following TBI.
引用
收藏
页码:6 / 12
页数:7
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