The Efficacy and Safety of Deep Brain Stimulation of Combined Anterior Limb of Internal Capsule and Nucleus Accumbens (ALIC/NAcc-DBS) for Treatment-Refractory Obsessive-Compulsive Disorder: Protocol of a Multicenter, Randomized, and Double-Blinded Study

被引:4
作者
Xu, Tingting [1 ]
Gao, Yuan [2 ]
Li, Bin [2 ]
Jiang, Jiaxin [2 ]
Guo, Huirong [3 ]
Liu, Xianzhi [3 ]
Huang, Hongxing [4 ]
Cheng, Yuqi [5 ]
Yu, Hualin [5 ]
Hu, Jie [6 ]
Wu, Xi [7 ]
Wang, Wei [2 ]
Wang, Zhen [1 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China
[2] Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[4] Brains Hosp Hunan Prov, Changsha 410015, Peoples R China
[5] Kunming Med Univ, Affiliated Hosp 1, Kunming 650031, Yunnan, Peoples R China
[6] Fudan Univ, Huashan Hosp, Shanghai 200040, Peoples R China
[7] Navy Mil Med Univ, Changhai Hosp, Shanghai 200086, Peoples R China
关键词
obsessive-compulsive disorder; deep brain stimulation; anterior limb of internal capsule; nucleus accumbens; ELECTRICAL-STIMULATION; RATING-SCALE;
D O I
10.3390/brainsci12070933
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Backgrounds: Deep brain stimulation (DBS) is an emerging and promising therapeutic approach for treatment-refractory obsessive-compulsive disorder (OCD). The most common DBS targets include the anterior limb of internal capsule (ALIC) and nucleus accumbens (NAcc). This protocol aims to explore the efficacy and safety of the combined ALIC- and NAcc-DBS for treatment-refractory OCD. Methods: We will recruit 64 patients with refractory OCD from six centers, randomly allocate them to active and sham-stimulation groups through a three-month double-blind phase, then enter a three-month open-label phase. In the open-label stage, both groups experience real stimulation. Outcome measures: The primary outcome will be the efficacy and safety of combined ALIC- and NAcc-DBS, determined by treatment response rate between the active and sham-stimulation groups at the double-blind stage and spontaneously reported adverse events. The secondary outcomes are comparisons of change in Y-BOCS, CGI, HAMD, and HAMA scores at the third and sixth months compared to baseline between the active and sham-control groups, as well as the scores of the third month minus the sixth month between the two groups.
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页数:10
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