Treatment of invasive breast carcinoma with ultrasound-guided radiofrequency ablation

Background: Radiofrequency ablation (RFA) is a minimally invasive thermal ablation technique. This study reports,the safety and efficacy of RFA as a minimally invasive strategy for breast, cancers <3 cm diameter in postmenopausal women. Methods: Twenty-two postmenopausal women (aged 60 years or older) with clinical T-I NO core biopsy proven breast cancers were studied. Thermocoagulation was undertaken using a sonographically guided RF probe under local anesthesia and sedation. The ablated tumor was resected between I and 2 weeks later. Endpoints were technical success, completeness of tumor kill, marginal clearance, skin damage, and patient reports of pain and procedural acceptability. Results: The procedure was well tolerated and cosmesis was excellent. Pathology revealed a central ablation zone surrounded by hyperemia. Coagulative necrosis was complete in 19 of 22 patients. Disease at the ablation zone margin was found in 3 patients and 5 patients had disease distant to the ablation zone consisting of multifocal tumors (2), in-transit metastasis (1), and extensive ductal carcinoma in situ with microinvasive carcinoma (2). Ninety-five percent of patients would be willing to have RFA again. Conclusions: Radiofrequency ablation can be safely applied in an outpatient setting with acceptable patient tolerance. By itself, RFA cannot be considered effective local therapy. Trials to evaluate RFA complemented with breast irradiation are justified. (C) 2003 Excerpta Medica, Inc. All rights reserved.