HUMAN EMBRYONIC STEM CELLS - REGULATION OF PLURIPOTENCY AND DIFFERENTIATION

被引：0

作者：

Witkowska, Anna ^{[1
]}

Ciemerych, Maria Anna ^{[2
]}

Suwinska, Aneta ^{[1
]}

机构：

[1] Uniwersytet Warszawski, Zaklad Embriol, Inst Zool, Wydzial Biol, PL-02096 Warsaw, Poland

[2] Uniwersytet Warszawski, Zaklad Cytol, Inst Zool, Wydzial Biol, PL-02096 Warsaw, Poland

来源：

POSTEPY BIOLOGII KOMORKI | 2010年 / 37卷 / 01期

关键词：

human embryonic stem cells; pluripotency; Oct3/4; Nanog; FIBROBLAST-GROWTH-FACTOR; PROLONGED UNDIFFERENTIATED GROWTH; SERUM REPLACEMENT MEDIUM; HUMAN FEEDER CELLS; SELF-RENEWAL; FREE CULTURE; MAINTAIN PLURIPOTENCY; GENE-EXPRESSION; MOUSE; LINES;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Embryonic stem (ES) cells derived from preimplantation embryos at the blastocyst. stage are unique in their unlimited self-renewal ability and pluripotency allowing their differentiation into any cell type for these reasons ES cells are considered as a perfect material for basic research on their differentiation capacities, and also for the studies devoted to the development of novel therapies This article focuses at the mechanisms regulating E-S cells pluripotency, self-renewal. and also influencing their differentiation. It also describes alternative methods of the derivation of pluripotent stem cell lines, which do not require embryo destruction and thus do not raise ethical issues A special attention is paid to the development of ES cell culture

引用

页码：23 / 40

页数：18

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