Bovine adenovirus type 3 pneumonia in dexamethasone-treated calves

被引：6

作者：

Narita, M ^{[1
]}

Yamada, M ^{[1
]}

Tsuboi, T ^{[1
]}

Kawashima, K ^{[1
]}

机构：

[1] Natl Inst Anim Hlth, Kamikita, Aomori 0392586, Japan

来源：

VETERINARY PATHOLOGY | 2003年 / 40卷 / 02期

关键词：

bovine adenovirus type 3; bronchoalveolar lavage fluid; calves; CD8; dexamethasone treatment; immunohistocbernistry; pneumonia;

D O I：

10.1354/vp.40-2-128

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The effects of immunosuppression were examined in 1.5-month-old calves that were given dexamethasone (DM) before endobronchial inoculation with bovine adenovirus type 3 (BAV-3). Immunohistopathologically, severe necrotizing bronchiolitis with eosinophilic and basophilic intranuclear inclusion bodies was observed both in DM-treated 1.5-month-old infected calves and in non-DM-treated 7-day-old infected calves. These inclusion bodies were correlated with the detection of BAV-3 antigen and viral particles. The presence of inclusion bodies in the desquamated epithelial cells or of BAV-3 antigen, or both, correlated well with the isolated level of BAV-3 in bronchoalveolar lavage (BAL) fluid. Few immunoglobulin (IgG, IgM, and IgA)containing B lymphocytes or CD8+ T lymphocytes infiltrated the pneumonic lesion in both the 7-day-old and the DM-treated 1.5-month-old infected calves. Thus, depletion of CD8+ T lymphocytes in calves might influence the clearance of BAV-3 from respiratory tissues.

引用

页码：128 / 135

页数：8

共 25 条

[1] IMMUNOGLOBULIN CONTAINING CELLS IN THE BRONCHOPULMONARY SYSTEM OF NON-PNEUMONIC AND PNEUMONIC CALVES [J].