A new synthesis of 3-hydroxy-2,3-dihydro-1,4-benzodioxin-2-carboxamides and 3-aminomethylene-1,4-benzodioxin-2(3H)-one derivatives

被引：4
作者：
Bozzo, C
Pujol, MD
Solans, X
Font-Bardia, M
机构：
[1] Univ Barcelona, Fac Farm, CSIC, Quim Farmaceut Lab,Unitat Associada, E-08028 Barcelona, Spain
[2] Univ Barcelona, Dept Cristallog Mineral & Deposits Minerals, E-08028 Barcelona, Spain
来源：
TETRAHEDRON | 2003年 / 59卷 / 08期
关键词：
1,4-benzodioxin-2-carboxamides; 1,4-benzodioxin-2-carboxylic esters; 2,3-disubstituted-1,4-benzodioxines; Michael addition;
D O I：
10.1016/S0040-4020(03)00025-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 1,4-benzodioxin-2-carboxylic esters or carboxamides react with nucleophilic amines to give access to 3-hydroxy-2,3-dihydro- 1,4-benzodioxin-2-carboxamides and 3-aminomethyn-1,4-benzodioxin-2(3H)-one precursors of potential therapeutical compounds. The basic environment (K2CO3 or amine) facilitates the process. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1227 / 1236
页数：10
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