β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly

被引：28

作者：

Svenningsson, Anna L. ^{[1
,2
]}

Stomrud, Erik ^{[1
,2
]}

Insel, Philip S. ^{[1
]}

Mattsson, Niklas ^{[1
,3
]}

Palmqvist, Sebastian ^{[1
,3
]}

Hansson, Oskar ^{[1
,2
]}

机构：

[1] Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Lund, Sweden

[2] Skane Univ Hosp, Memory Clin, Malmo, Sweden

[3] Lund Univ, Skane Univ Hosp, Dept Neurol, Lund, Sweden

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

CEREBROSPINAL-FLUID BIOMARKERS; ALZHEIMERS-DISEASE; CORTICAL THICKNESS; BRAIN STRUCTURE; AD DEMENTIA; DEPOSITION; DECLINE; TAU; INDIVIDUALS; MRI;

D O I：

10.1038/s41598-019-47638-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of cerebrospinal fluid biomarkers for amyloid-beta (A beta 42/40), neuroinflammation (YKL-40), and neurodegeneration and tau pathology (T-tau and P-tau) as well as MRI measures of white-matter lesions, hippocampal volume (HV), and regional cortical thickness. We found that A beta positivity and HV were independently associated with memory. Results differed depending on age, with memory being associated with HV (but not A beta) in older participants (73.3-88.4 years), and with A beta (but not HV) in relatively younger participants (65.2-73.2 years). This indicates that A beta and atrophy are independent contributors to memory variability in cognitively healthy elderly and that A beta mainly affects memory in younger elderly individuals. With advancing age, the effect of brain atrophy overshadows the effect of A beta on memory function.

引用

页数：9

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