Helicobacter pylori VacA, a paradigm for toxin multifunctionality

被引：415
作者：
Cover, TL
Blanke, SR
机构：
[1] Vanderbilt Univ, Sch Med, Dept Med, Div Infect Dis, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Div Infect Dis, Nashville, TN 37232 USA
[3] Univ Illinois, Dept Microbiol & Mol Genet, Urbana, IL 61801 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 04期
关键词：
D O I：
10.1038/nrmicro1095
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to successfully colonize their hosts. In recent years, there has been increased recognition that many bacterial toxins are multifunctional proteins that can have pleiotropic effects on mammalian cells and tissues. In this review, we examine a multifunctional toxin (VacA) that is produced by the bacterium Helicobacter pylori. The actions of H. pylori VacA represent a paradigm for how bacterial secreted toxins contribute to colonization and virulence in multiple ways.
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页码：320 / 332
页数：13
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