Thermal Study in Solid State of Zn(II)-Diclofenac Complex: Behavior Kinetic of the Dehydration, Transition Phase and Thermal Decomposition

被引：7

作者：

Kobelnik, Marcelo ^{[1
]}

Quarcioni, Valdecir Angelo ^{[2
]}

Ribeiro, Clovis Augusto ^{[3
]}

Vieira Capela, Jorge Manuel ^{[3
]}

Dias, Diogenes dos Santos ^{[3
]}

Crespi, Marisa Spirandeli ^{[3
]}

机构：

[1] Sao Paulo State Univ, Inst Biociencias Letras & Ciencias Exatas, BR-15070000 Sao Jose Do Rio Preto, SP, Brazil

[2] IPT, BR-05508901 Sao Paulo, Brazil

[3] Sao Paulo State Univ, Inst Quim, BR-14800900 Araraquara, SP, Brazil

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2010年 / 57卷 / 3A期

关键词：

Zn(II)-diclofenac complex; Thermal behavior; Transition phase; Kinetic; INTERESTING ANTIINFLAMMATORY ACTIVITY; METAL-COMPLEXES; DICLOFENAC; ENERGY;

D O I：

10.1002/jccs.201000057

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The dehydration, thermal decomposition and transition phase stage of Zn(II)-diclofenac compound were studied by simultaneous TG-DTA and DSC techniques. The TG and DSC curves of this compound were obtained with the mass of sample of 2 and 5 mg. Additionally, DSC curves were carried out in opened and closed alpha-alumina pans under static and nitrogen atmosphere. The DTA and DSC curves show that this compound possesses exothermic transition phase between 170-180 degrees C, which it is irreversible (monotropic reaction) The kinetics study of this transition phase stage was evaluated by DSC under non-isothermal conditions. The obtained data were evaluated with the isoconversional method, where the values of activation energy (E(a) / kJ mol(-1)) was plotted in function of the conversion degree (alpha). The results show that due to mass sample, different activation energies were obtained From these curves a tendency can be seen where the plots maintain the same profile for closed lids and almost run parallel to each other.

引用

页码：384 / 390

页数：7

共 13 条

[1] Spectroscopic characteristics and thermal properties of divalent metal complexes of diclofenac [J].

Bucci, R ;

Magrì, AD ;

Magrì, AL ;

Napoli, A .

POLYHEDRON, 2000, 19 (24-25) :2515-2520

[2] Rational approximations of the Arrhenius integral using Jacobi fractions and gaussian quadrature [J].

Capela, Jorge M. V. ;

Capela, Marisa V. ;

Ribeiro, Clovis A. .

JOURNAL OF MATHEMATICAL CHEMISTRY, 2009, 45 (03) :769-775

[3]

Galwey A.K., 1999, THERMAL DECOMPOSITIO, V1st

[4] Is the science of thermal analysis kinetics based on solid foundations? A literature appraisal [J].

Galwey, AK .

THERMOCHIMICA ACTA, 2004, 413 (1-2) :139-183

[5] Comparison of isothermal and dynamic methods for the determination of activation energy by thermogravimetry [J].

Howell, BA ;

Ray, JA .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2006, 83 (01) :63-66

[6] Decomposition kinetics of iron (III)-diclofenac compound [J].

Kobelnik, M. ;

Bernabe, Giseli Aparecida ;

Ribeiro, C. A. ;

Capela, J. M. V. ;

Fertonani, F. L. .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2009, 97 (02) :493-496

[7]

Kobelnik M, 2010, J THERM ANAL CALORIM, V102, P1167, DOI 10.1007/s10973-010-0787-8

[8] Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity [J].

Kovala-Demertzi, D .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 79 (1-4) :153-157

[9] Metal ion-drug interactions.: Preparation and properties of manganese (II), cobalt (II) and nickel (II) complexes of diclofenac with potentially interesting anti-inflammatory activity:: Behavior in the oxidation of 3,5-di-tert-butyl-o-catechol [J].

Kovala-Demertzi, D ;

Hadjikakou, SK ;

Demertzis, MA ;

Deligiannakis, Y .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1998, 69 (04) :223-229

[10] Synthesis and characterization of tetrakis-mu-2-[(2,6dichlorophenyl)amino]benzeneacetodiaquodicopper(II) dihydrate and tetrakis-mu-2-[(2,6dichlorophenyl)amino]benzeneaceto dimethylformamidodicopper(II) [J].

KovalaDemertzi, D ;

Theodorou, A ;

Demertzis, MA ;

Raptopoulou, CP ;

Terzis, A .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1997, 65 (03) :151-157

← 1 2 →