Bromo-Substituted Diketopyrrolopyrrole Derivative with Specific Targeting and High Efficiency for Photodynamic Therapy

被引：77

作者：

Cai, Yu ^{[1
,2
]}

Tang, Qianyun ^{[1
,2
]}

Wu, Xiujuan ^{[3
]}

Si, Weili ^{[1
,2
]}

Zhang, Qi ^{[3
]}

Huang, Wei ^{[1
,2
]}

Dong, Xiaochen ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ NanjingTech, Key Lab Flexible Elect KLOFE, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Tech Univ NanjingTech, IAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

[3] Nanjing Tech Univ NanjingTech, Sch Pharmaceut Sci, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 17期

基金：

中国国家自然科学基金;

关键词：

photodynamic therapy; photosensitizers; diketopyrrolopyrrole; hyaluronic acid; bromo-substituted; HYALURONIC-ACID NANOPARTICLES; ORGANIC SOLAR-CELLS; DRUG-DELIVERY; CANCER-CELLS; PHOTOSENSITIZER; EMISSION; DESIGN; THERANOSTICS; TRANSISTORS; MOLECULE;

D O I：

10.1021/acsami.6b01533

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.

引用

页码：10737 / 10742

页数：6

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