Probiotics and prebiotics in ulcerative colitis

被引：97

作者：

Derikx, Lauranne A. A. P. ^{[1
]}

Dieleman, Levinus A. ^{[2
]}

Hoentjen, Frank ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Ctr Inflammatory Bowel Dis, Dept Gastroenterol & Hepatol, Med Ctr, POB 9101,Code 455, NL-6500 HB Nijmegen, Netherlands

[2] Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2016年 / 30卷 / 01期

关键词：

Ulcerative colitis; Microbiota; Probiotics; Prebiotics; INFLAMMATORY-BOWEL-DISEASE; BIFIDOBACTERIA-FERMENTED MILK; GERMINATED BARLEY FOODSTUFF; RANDOMIZED CONTROLLED-TRIAL; ESCHERICHIA-COLI; CROHNS-DISEASE; MAINTAINING REMISSION; CLINICAL-TRIAL; DOUBLE-BLIND; GUT MICROBIOTA;

D O I：

10.1016/j.bpg.2016.02.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The intestinal microbiota is one of the key players in the etiology of ulcerative colitis. Manipulation of this microflora with probiotics and prebiotics is an attractive strategy in the management of ulcerative colitis. Several intervention studies for both the induction and maintenance of remission in ulcerative colitis patients have been performed. Most of these studies evaluated VSL#3 or E. Coli Nissle 1917 and in general there is evidence for efficacy of these agents for induction and maintenance of remission. However, studies are frequently underpowered, lack a control group, and are very heterogeneous investigating different probiotic strains in different study populations. The absence of well powered robust randomized placebo-controlled trials impedes the widespread use of probiotics and prebiotics in ulcerative colitis. However, given the promising results that are currently available, probiotics and prebiotics may find their way to the treatment algorithm for ulcerative colitis in the near future. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：55 / 71

页数：17

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