Emerging role of neuregulin as a modulator of muscle metabolism

被引：57

作者：

Guma, Anna ^{[1
,2
,4
]}

Martinez-Redondo, Vicente ^{[1
,2
,4
]}

Lopez-Soldado, Iliana ^{[1
,3
,4
]}

Canto, Carles ^{[1
]}

Zorzano, Antonio ^{[1
,3
,4
]}

机构：

[1] Univ Barcelona, Dept Biochem & Mol Biol, Fac Biol, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain

[3] Inst Biomed Res, Barcelona, Spain

[4] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2010年 / 298卷 / 04期

关键词：

ErbB receptors; exercise; glucose transport; insulin; mitochondrial biogenesis; RECEPTOR GENE-EXPRESSION; SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; PROTEIN-KINASE; OXIDATIVE-PHOSPHORYLATION; MYOGENIC DIFFERENTIATION; NEUROMUSCULAR SYNAPSE; CARDIAC DEVELOPMENT; SIGNALING PATHWAYS; ERBB RECEPTORS;

D O I：

10.1152/ajpendo.00541.2009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Guma A, Martinez-Redondo V, Lopez-Soldado I, Canto C, Zorzano A. Emerging role of neuregulin as a modulator of muscle metabolism. Am J Physiol Endocrinol Metab 298: E742-E750, 2010. First published December 22, 2009; doi:10.1152/ajpendo.00541.2009.-Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.

引用

页码：E742 / E750

页数：9

共 90 条

[1] ERBB3 AND ERBB2/NEU MEDIATE THE EFFECT OF HEREGULIN ON ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN MUSCLE - DIFFERENTIAL EXPRESSION AT THE END-PLATE [J].