Irritable bowel syndrome: Role of gut microbiota

被引：0
作者：
Lajoie, Frederique [1 ]
Rousseau, Guy [1 ]
Blanquet-Diot, Stephanie [2 ]
Etienne-Mesmin, Lucie [2 ]
机构：
[1] Univ Montreal, Fac Med, Dept Pharmacol & Physiol, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada
[2] Univ Clermont Auvergne, INRAe, UMR454 MEDIS Microbiol Environm Digestif & Sante, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France
来源：
M S-MEDECINE SCIENCES | 2021年 / 37卷 / 6-7期
关键词：
FAECALIBACTERIUM-PRAUSNITZII; INTESTINAL MICROBIOTA; DIARRHEA; TRANSIT; MECHANISMS; DYSBIOSIS; SYMPTOMS;
D O I：
10.1051/medsci/2021095
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract with high prevalence. IBS, in particular the diarrheic subtype, is associated with alterations in gut microbiota composition and functionality, called dysbiosis. However, the treatment of this disease mainly relies on the patient's symptoms without considering the gut microbiota perturbations. In this review, we present epidemiological data about IBS-D. Then, we describe the main pathophysiological mechanisms associated with this disease, by focusing on gut microbiota alterations. We end up discussing the current therapies now available.
引用
收藏
页码：593 / 600
页数：8
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