The transition from bench to bedside: lessons learned in the creation of a new T-cell product for the clinic

被引：3

作者：

Barrett, J ^{[1
]}

Solomon, S ^{[1
]}

机构：

[1] NHLBI, Stem Cell Allotransplantat Sect, Hematol Branch, NIH, Bethesda, MD 20892 USA

来源：

CYTOTHERAPY | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1080/14653240410011936

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

While the technology of translational research is sometimes considered a poor relation to 'basic science', it has become a central focus of work to turn exciting new concepts into practical therapies. Here we use the example of selective T-cell depletion of allografted lymphocytes to illustrate the problems of scale-up, reproducibility, sterility, safety and regulatory concerns encountered during the bench to bedside process.

引用

页码：593 / 595

页数：3

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