SARS-CoV-2 Seroprevalence Survey Estimates Are Affected by Anti-Nucleocapsid Antibody Decline

被引：35

作者：

Bolotin, Shelly ^{[1
,2
,3
]}

Tran, Vanessa ^{[1
,3
]}

Osman, Selma ^{[1
]}

Brown, Kevin A. ^{[1
,2
]}

Buchan, Sarah A. ^{[1
,2
]}

Joh, Eugene ^{[1
]}

Deeks, Shelley L. ^{[1
,2
]}

Allen, Vanessa G. ^{[1
,3
]}

机构：

[1] Publ Hlth Ontario, Toronto, ON, Canada

[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 08期

关键词：

COVID-19; SARS-CoV-2; serology; seroprevalence;

D O I：

10.1093/infdis/jiaa796

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed 21 676 residual specimens from Ontario, Canada collected March-August 2020 to investigate the effect of antibody decline on SARS-CoV-2 seroprevalence estimates. Testing specimens orthogonally using Abbott (anti-nucleocapsid) and Ortho (anti-spike) assays, seroprevalence estimates were 0.4%-1.4%, despite ongoing disease activity. The geometric mean concentration (GMC) of antibody-positive specimens decreased over time (P = .015), and GMC of antibody-negative specimens increased over time (P = .0018). Association between the 2 tests decreased each month (P < .001), suggesting anti-nucleocapsid antibody decline. Lowering Abbott antibody index cutoff from 1.4 to 0.7 resulted in a 16% increase in positive specimens.

引用

页码：1334 / 1338

页数：5

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