Preparation and Characterization of Water-Soluble Chitosan Nanoparticles as Protein Delivery System

被引：129

作者：

Zhang, Hong-liang ^{[2
]}

Wu, Si-hui ^{[2
]}

Tao, Yi ^{[2
]}

Zang, Lin-quan ^{[2
]}

Su, Zheng-quan ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Coll Publ Hlth, Guangzhou 510240, Guangdong, Peoples R China

[2] Guangdong Pharmaceut Univ, Coll Pharm, Guangzhou 510006, Guangdong, Peoples R China

来源：

JOURNAL OF NANOMATERIALS | 2010年 / 2010卷

关键词：

DRUG; STABILITY; INSULINS;

D O I：

10.1155/2010/898910

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The objective of this study was to investigate the potential of water soluble chitosan as a carrier in the preparation of protein-loaded nanoparticles. Nanoparticles were prepared by ionotropic gelation of water-soluble chitosan (WSC) with sodium tripolyphosphate (TPP). Bovine serumalbumin (BSA) was applied as a model drug. The size and morphology of the nanoparticles were investigated as a function of the preparation conditions. The particles were spherical in shape and had a smooth surface. The size range of the nanoparticles was between 100 and 400 nm. Result of the in vitro studies showed that the WSC nanoparticles enhance and prolong the intestinal absorption of BSA. These results also indicated that WSC nanoparticles were a potential protein delivery system.

引用

页数：5

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