Therapeutic Challenges in Neuroendocrine Tumors

被引:4
|
作者
Legakis, Ioannis [1 ]
Saif, Muhammad Wasif [2 ]
Syrigos, Konstantinos [1 ]
机构
[1] Athens Sch Med, Sotiria Gen Hosp, Dept Internal Med 3, Oncol Unit, Athens, Greece
[2] Tufts Univ, Dept Hematol Oncol, Med Ctr, Boston, MA 02111 USA
关键词
Neuroendocrine tumors; biomarkers; somatostatin analogs; angiogenesis inhibitors; cytotoxic chemotherapy; radionuclide therapy; liver-targeted therapies; RECEPTOR RADIONUCLIDE THERAPY; PLASMA CHROMOGRANIN-A; ISLET-CELL TUMORS; LIVER-METASTASES; PHASE-II; GEP-NETS; SOMATOSTATIN ANALOGS; ENDOCRINE TUMORS; DIAGNOSIS; SURVIVAL;
D O I
10.2174/1871520617666170213113401
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Neuroendocrine tumors (NETs) are a diverse set of tumors, being genetically varied. NETs can be presented with a distinct clinical picture, due to the production of various hormones, or being silent. Based on community health clinical statistics, the frequency numbers and reported occurrence of NETs are increasing. Although the therapeutic options for NETs have expanded in recent years, clinical diagnosis is possible only when metastases are present, requiring chronic complicated medical management. A positive development is that the recent evolution of molecularly-targeted therapy in oncology promotes the evolution of innovative tools for the management of these tumors. A diverse assortment of medical specialists is needed to improve outcomes and orchestrate the therapeutic care plan for NET patients.
引用
收藏
页码:902 / 919
页数:18
相关论文
共 50 条
  • [1] Gastrointestinal neuroendocrine tumors (NETs): new diagnostic and therapeutic challenges
    Castano, J. P.
    Sundin, A.
    Maecke, H. R.
    Villabona, C.
    Vazquez-Albertino, R.
    Navarro, E.
    Oberg, K.
    CANCER AND METASTASIS REVIEWS, 2014, 33 (01) : 353 - 359
  • [2] New therapeutic approaches to metastatic gastroenteropancreatic neuroendocrine tumors: A glimpse into the future
    Cidon, Esther Una
    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2017, 9 (01) : 4 - 20
  • [3] Update in the management of gastroenteropancreatic neuroendocrine tumors
    Sedlack, Andrew J. H.
    Varghese, Diana Grace
    Naimian, Amirkia
    Anari, Pouria Yazdian
    Bodei, Lisa
    Hallet, Julie
    Riechelmann, Rachel P.
    Halfdanarson, Thor
    Capdevilla, Jaume
    Del Rivero, Jaydira
    CANCER, 2024, 130 (18) : 3090 - 3105
  • [4] Systemic treatment of neuroendocrine tumors with hepatic metastases
    Demirkan, Binnaz H. M.
    Eriksson, Barbro
    TURKISH JOURNAL OF GASTROENTEROLOGY, 2012, 23 (05) : 427 - 437
  • [5] Neuroendocrine tumors of the pancreas
    Milan, Stacey A.
    Yeo, Charles J.
    CURRENT OPINION IN ONCOLOGY, 2012, 24 (01) : 46 - 55
  • [6] Therapeutic Monitoring of Gastroenteropancreatic Neuroendocrine Tumors: The Challenges Ahead
    Sundin, Anders
    Rockall, Andrea
    NEUROENDOCRINOLOGY, 2012, 96 (04) : 261 - 271
  • [7] Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations
    Mpilla, Gabriel Benyomo
    Philip, Philip Agop
    El-Rayes, Bassel
    Azmi, Asfar Sohail
    WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (28) : 4036 - 4054
  • [8] Pancreatic neuroendocrine tumors: Challenges in an underestimated disease
    Viudez, A.
    De Jesus-Acosta, A.
    Carvalho, F. L.
    Vera, R.
    Martin-Algarra, S.
    Ramirez, N.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2016, 101 : 193 - 206
  • [9] Clinical Aspects, Diagnostic Challenges and Management of Patients with Neuroendocrine Tumors (NETs)
    Spizzo, Gilbert
    Bernardini, Karin
    Pieramico, Oreste
    Buratti, Thomas
    Platzgummer, Stefan
    Farsad, Mohsen
    Schmitt, Anja M.
    Perren, Aurel
    Vogelsang, Holger
    Promegger, Rupert
    Bale, Reto
    Gabriel, Michael
    Nevinny, Meinhard
    Gastl, Guenther
    Mitterer, Manfred
    ONKOLOGIE, 2011, 34 (03): : 139 - 146
  • [10] Neuroendocrine Tumors
    Basuroy, Ron
    Srirajaskanthan, Raj
    Ramage, John K.
    GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2016, 45 (03) : 487 - +