Synthesis of novel heterocycle-fused furo[3,4-d]-isoxazoles via ring transformation of 2-isoxazoline-2-oxides by Lewis acid

被引：9
作者：
Harada, K
Kaji, E
Sasaki, K
Zen, S
机构：
[1] School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku
来源：
HETEROCYCLES | 1996年 / 42卷 / 01期
关键词：
D O I：
10.3987/COM-95-S26
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of five-membered heterocycle-substituted 2-isoxazoline-2-oxides (2, 3, and 4) with titanium tetrachloride afforded novel heterocycle-fused furo[3,4-d]isoxazoles (5, 6 and 7), respectively. This transformation was applied to indole-substituted 2-isoxazoline-2-oxide (8) to give the corresponding fused furo[3,4-d]isoxazole (9) and indolo[2,3-b]-1-pyrroline-1-oxide (10).
引用
收藏
页码：289 / 304
页数：16
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