Recent Strategies for Treating Stage IV Gastric Cancer: Roles of Palliative Gastrectomy, Chemotherapy, and Radiotherapy

被引:3
|
作者
Izuishi, Kunihiko [1 ]
Mori, Hirohito [2 ,3 ]
机构
[1] Takamatsu Hosp, Dept Surg Gastroenterol, Federat Publ Serv & Affiliated Personnel Aid Asso, 4-18 Tenjinmae, Takamatsu, Kagawa 7600018, Japan
[2] Kagawa Univ, Sch Med, Dept Gastroenterol, Takamatsu, Kagawa 7610793, Japan
[3] Kagawa Univ, Sch Med, Dept Neurol, Takamatsu, Kagawa 7610793, Japan
关键词
Stage IV gastric cancer; palliative gastrectomy; chemotherapy; radiotherapy; bypass; NEUTROPHIL-LYMPHOCYTE RATIO; S-1 PLUS CISPLATIN; PHASE-III TRIAL; 1ST-LINE THERAPY; CLINICAL-SIGNIFICANCE; PROGNOSTIC-FACTOR; DOUBLE-BLIND; CARCINOMA; RESECTION; SURVIVAL;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Recently, many strategies have been reported for the effective treatment of gastric cancer. However, the strategy for treating stage IV gastric cancer remains controversial. Conducting a prospective phase III study in stage IV cancer patients is difficult because of heterogeneous performance status, age, and degree of cancer metastasis or extension. Due to poor prognosis, the variance in physical status, and severe symptoms, it is important to determine the optimal strategy for treating each individual stage IV patient. In the past decade, many reports have addressed topics related to stage IV gastric cancer: the 7th Union for International Cancer Control (UICC) TNM staging system has altered its stage IV classification; new chemotherapy regimens have been developed through the randomized ECF for advanced and locally advanced esophagogastric cancer (REAL)-II, S-1 plus cisplatin versus S-1 in RCT in the treatment for stomach cancer (SPIRITS), trastuzumab for gastric cancer (ToGA), ramucirumab monotherapy for previously-treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD), and ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously-treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW) trials; and the survival efficacy of palliative gastrectomy has been denied by the reductive gastrectomy for advanced tumor in three Asian countries (REGATTA) trial. Current strategies for treating stage IV patients can be roughly divided into the following five categories: palliative gastrectomy, chemotherapy, radiotherapy, gastric stent, or bypass. In this article, we review recent publications and guidelines along with above categories in the light of individual symptoms and prognosis.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 50 条
  • [41] Effect of palliative surgery chemotherapy, and radiation in stage IV pancreatic cancer.
    Vuong, Brooke
    Dehal, Ahmed
    Graff-Baker, Amanda N.
    Chang, Shu-Ching
    Foshag, Leland
    Bilchik, Anton
    Goldfarb, Melanie R.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [42] Palliative surgery for advanced stage (stage IV) gastric adenocarcinoma
    Nazli, Okay
    Yaman, Ismail
    Tansug, Tugrul
    Isguder, Ali Serdar
    Bozdag, Ali Dogan
    Bolukbasi, Hakan
    HEPATO-GASTROENTEROLOGY, 2007, 54 (73) : 298 - 303
  • [43] The long-term prognostic difference between gastrectomy with and without preoperative chemotherapy in patients with clinical stage IV gastric cancer
    Park, Ji-Hyeon
    Yang, Jun-Young
    Park, Yeon-Ho
    Lee, Woon-Kee
    ASIAN JOURNAL OF SURGERY, 2019, 42 (10) : 922 - 929
  • [44] A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Stage IV Peritoneal Disease
    Badgwell, B.
    Ikoma, N.
    Estrella, J.
    Chowdhuri, S. Roy
    Das, P.
    Minsky, B.
    Wang, X.
    Mansfield, P.
    Ajani, J.
    ANNALS OF SURGICAL ONCOLOGY, 2020, 27 (SUPPL 1) : S8 - S8
  • [45] Radical Gastrectomy After Chemotherapy May Prolong Survival in Stage IV Gastric Cancer: A Korean Multi-institutional Analysis
    Ho Seok Seo
    Kyo Young Song
    Yoon Ju Jung
    Seung Man Park
    Hae Myung Jeon
    Wook Kim
    Hyung Min Chin
    Jin-Jo Kim
    Sung Keun Kim
    Kyung Hwa Chun
    Jeong Goo Kim
    Jun Hyun Lee
    Han Hong Lee
    Dong Jin Kim
    Han Mo Yoo
    Chang Hyun Kim
    Eun Young Kim
    Cho Hyun Park
    World Journal of Surgery, 2018, 42 : 3286 - 3293
  • [46] A phase II trial of cytoreduction, gastrectomy, and hyperthermic intraperitoneal perfusion with chemotherapy for patients with gastric cancer and stage IV peritoneal disease
    Badgwell, Brian D.
    Ikoma, Naruhiko
    Murphy, Mariela A. Blum
    Wang, Xuemei
    Estrella, Jeannelyn
    Roy-Chowdhuri, Sinchita
    Das, Prajnan
    Minsky, Bruce D.
    Mansfield, Paul F.
    Ajani, Jaffer A.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
  • [47] Radical Gastrectomy After Chemotherapy May Prolong Survival in Stage IV Gastric Cancer: A Korean Multi-institutional Analysis
    Seo, Ho Seok
    Song, Kyo Young
    Jung, Yoon Ju
    Park, Seung Man
    Jeon, Hae Myung
    Kim, Wook
    Chin, Hyung Min
    Kim, Jin-Jo
    Kim, Sung Keun
    Chun, Kyung Hwa
    Kim, Jeong Goo
    Lee, Jun Hyun
    Lee, Han Hong
    Kim, Dong Jin
    Yoo, Han Mo
    Kim, Chang Hyun
    Kim, Eun Young
    Park, Cho Hyun
    WORLD JOURNAL OF SURGERY, 2018, 42 (10) : 3286 - 3293
  • [48] Survival benefit of palliative gastrectomy followed by chemotherapy in stage IV gastric signet ring cell carcinoma patients: A large population-based study
    Shi, Tao
    Song, Xueru
    Liu, Qin
    Yang, Yang
    Yu, Lixia
    Liu, Baorui
    Wei, Jia
    CANCER MEDICINE, 2019, 8 (13): : 6010 - 6020
  • [49] Palliative chemotherapy for advanced gastric cancer
    Wöhrer, SS
    Raderer, A
    Hejna, A
    ANNALS OF ONCOLOGY, 2004, 15 (11) : 1585 - 1595
  • [50] Gastrectomy for Stage IV Gastric Cancer. A Systematic Review and Meta-analysis
    Lasithiotakis, Konstantinos
    Antoniou, Stavros A.
    Antoniou, George A.
    Kaklamanos, Ioannis
    Zoras, Odysseas
    ANTICANCER RESEARCH, 2014, 34 (05) : 2079 - 2085