Predicting residual kidney function in hemodialysis patients using serum β-trace protein and β2-microglobulin

Residual kidney function (RKF) contributes significant solute clearance in hemodialysis patients. Kidney Diseases Outcomes Quality Initiative (KDOQI) guidelines suggest that hemodialysis dose can be safely reduced in those with residual urea clearance (KRU) of 2 ml/min/1.73 m(2) or more. However, serial measurement of RKF is cumbersome and requires regular interdialytic urine collections. Simpler methods for assessing RKF are needed. beta-trace protein ((beta TP) and beta 2-microglobulin (beta 2M) have been proposed as alternative markers of RKF. We derived predictive equations to estimate glomerular filtration rate (GFR) and KRU based on serum beta TP and beta 2M from 191 hemodialysis patients based on standard measurements of KRU and GFR (mean of urea and creatinine clearances) using interdialytic urine collections. These modeled equations were tested in a separate validation cohort of 40 patients. A prediction equation for GFR that includes both beta TP and beta 2M provided a better estimate than either alone and contained the terms 1/beta TP, 1/beta 2M, 1/serum creatinine, and a factor for gender. The equation for KRU contained the terms 1/beta TP, 1/beta 2M, and a factor for ethnicity. Mean bias between predicted and measured GFR was 0.63 ml/min and 0.50 ml/min for KRU. There was substantial agreement between predicted and measured KRU at a cut-off level of 2 ml/min/1.73 m(2). Thus, equations involving beta TP and beta 2M provide reasonable estimates of RKF and could potentially be used to identify those with KRU of 2 ml/min/1.73 m2 or more to follow the KDOQI incremental hemodialysis algorithm. Copyright (C) 2016, International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).