IGFBP6 Regulates Cell Apoptosis and Migration in Glioma

被引：22
作者：
Bei, Yuanqi [2 ,3 ,4 ,5 ]
Huang, Qingfeng [1 ]
Shen, Jianhong [1 ]
Shi, Jinlong [1 ]
Shen, Chaoyan [2 ,3 ,4 ]
Xu, Peng [4 ]
Chang, Hao [6 ]
Xia, Xiaojie [2 ,3 ,4 ]
Xu, Li [7 ]
Ji, Bin [2 ,3 ]
Chen, JianGuo [1 ]
机构：
[1] Nantong Univ, Dept Neurosurg, Affiliated Hosp, Xisi Rd 20, Nantong 226001, Peoples R China
[2] Nantong Univ, Affiliated Hosp, Dept Radiat Oncol, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China
[3] Nantong Univ, Affiliated Hosp, Res Ctr Clin Med, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China
[4] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China
[5] Nantong Univ, Affiliated Canc Hosp, Dept Intens Care Unit, Nantong 226361, Peoples R China
[6] Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Neurosurg, Wuxi 214002, Peoples R China
[7] Suzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215000, Peoples R China
来源：
CELLULAR AND MOLECULAR NEUROBIOLOGY | 2017年 / 37卷 / 05期
关键词：
IGFBP6; Glioma; Apoptosis; Migration; Prognosis; FACTOR-BINDING PROTEIN-6; RANDOMIZED PHASE-III; GLIOBLASTOMA; PROLIFERATION; INVASION;
D O I：
10.1007/s10571-016-0426-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The insulin-like growth factor binding protein 6 (IGFBP6), as an inhibitor of IGF-II actions, plays an important role in inhibiting survival and migration of tumor cells. In our study, we intended to demonstrate the biological function of IGFBP6 in the development of glioma and its clinical significance. Firstly, Western blot and immunohistochemistry revealed that the expression of IGFBP6 inversely correlated with glioma grade. Secondly, multivariate analysis with the Cox proportional hazards model and Kaplan-Meier analysis indicated that IGFBP6 could be an independent prognostic factor for the survival of glioma patients. In addition, overexpression of IGFBP6 induced glioma cell apoptosis, and depletion of IGFBP6 had the opposite action. Finally, overexpression of IGFBP6 inhibited migration of glioma cells, and depletion of IGFBP6 had the opposite action. Together our findings suggest that IGFBP6 might be an important regulator and prognostic factor for glioma.
引用
收藏
页码：889 / 898
页数：10
相关论文
共 25 条
  • [1] Central nervous system
    Adamson, D. Cory
    Rasheed, B. Ahmed K.
    McLendon, Roger E.
    Bigner, Darell D.
    [J]. CANCER BIOMARKERS, 2011, 9 (1-6) : 193 - 210
  • [2] Insulin-like growth factor binding protein-6: The "forgotten" binding protein?
    Bach, LA
    [J]. HORMONE AND METABOLIC RESEARCH, 1999, 31 (2-3) : 226 - 234
  • [3] IGFBP-6 five years on; not so 'forgotten'?
    Bach, LA
    [J]. GROWTH HORMONE & IGF RESEARCH, 2005, 15 (03) : 185 - 192
  • [4] Recent insights into the actions of IGFBP-6
    Bach, Leon A.
    [J]. JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2015, 9 (02) : 189 - 200
  • [5] Insulin-like growth factor-binding protein-6 and cancer
    Bach, Leon A.
    Fu, Ping
    Yang, Zhiyong
    [J]. CLINICAL SCIENCE, 2013, 124 (3-4) : 215 - 229
  • [6] Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD
    Ding, Zongmei
    Liu, Yonghua
    Yao, Li
    Wang, Donglin
    Zhang, Jianguo
    Cui, Gang
    Yang, Xiaojing
    Huang, Xianting
    Liu, Fang
    Shen, Aiguo
    [J]. CELL CYCLE, 2015, 14 (13) : 2149 - 2159
  • [7] Gene expression profiling of gliomas strongly predicts survival
    Freije, WA
    Castro-Vargas, FE
    Fang, ZX
    Horvath, S
    Cloughesy, T
    Liau, LM
    Mischel, PS
    Nelson, SF
    [J]. CANCER RESEARCH, 2004, 64 (18) : 6503 - 6510
  • [8] Tumour-cell invasion and migration: Diversity and escape mechanisms
    Friedl, P
    Wolf, K
    [J]. NATURE REVIEWS CANCER, 2003, 3 (05) : 362 - 374
  • [9] Promotion of cancer cell migration - An insulin-like growth factor (IGF)-independent action of IGF-binding protein-6
    Fu, Ping
    Thompson, Julian A.
    Bach, Leon A.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (31) : 22298 - 22306
  • [10] Cross-Talk Between MAP Kinase Pathways Is Involved in IGF-Independent, IGFBP-6-Induced Rh30 Rhabdomyosarcoma Cell Migration
    Fu, Ping
    Liang, Guang Jun
    Khot, Sahil S.
    Phan, Robert
    Bach, Leon A.
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 224 (03) : 636 - 643
123