IGFBP6 Regulates Cell Apoptosis and Migration in Glioma

被引：23

作者：

Bei, Yuanqi ^{[2
,3
,4
,5
]}

Huang, Qingfeng ^{[1
]}

Shen, Jianhong ^{[1
]}

Shi, Jinlong ^{[1
]}

Shen, Chaoyan ^{[2
,3
,4
]}

Xu, Peng ^{[4
]}

Chang, Hao ^{[6
]}

Xia, Xiaojie ^{[2
,3
,4
]}

Xu, Li ^{[7
]}

Ji, Bin ^{[2
,3
]}

Chen, JianGuo ^{[1
]}

机构：

[1] Nantong Univ, Dept Neurosurg, Affiliated Hosp, Xisi Rd 20, Nantong 226001, Peoples R China

[2] Nantong Univ, Affiliated Hosp, Dept Radiat Oncol, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China

[3] Nantong Univ, Affiliated Hosp, Res Ctr Clin Med, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China

[4] Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Peoples R China

[5] Nantong Univ, Affiliated Canc Hosp, Dept Intens Care Unit, Nantong 226361, Peoples R China

[6] Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Neurosurg, Wuxi 214002, Peoples R China

[7] Suzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215000, Peoples R China

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2017年 / 37卷 / 05期

关键词：

IGFBP6; Glioma; Apoptosis; Migration; Prognosis; FACTOR-BINDING PROTEIN-6; RANDOMIZED PHASE-III; GLIOBLASTOMA; PROLIFERATION; INVASION;

D O I：

10.1007/s10571-016-0426-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin-like growth factor binding protein 6 (IGFBP6), as an inhibitor of IGF-II actions, plays an important role in inhibiting survival and migration of tumor cells. In our study, we intended to demonstrate the biological function of IGFBP6 in the development of glioma and its clinical significance. Firstly, Western blot and immunohistochemistry revealed that the expression of IGFBP6 inversely correlated with glioma grade. Secondly, multivariate analysis with the Cox proportional hazards model and Kaplan-Meier analysis indicated that IGFBP6 could be an independent prognostic factor for the survival of glioma patients. In addition, overexpression of IGFBP6 induced glioma cell apoptosis, and depletion of IGFBP6 had the opposite action. Finally, overexpression of IGFBP6 inhibited migration of glioma cells, and depletion of IGFBP6 had the opposite action. Together our findings suggest that IGFBP6 might be an important regulator and prognostic factor for glioma.

引用

页码：889 / 898

页数：10

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