Microtubules and resistance to tubulin-binding agents

被引：940

作者：

Kavallaris, Maria ^{[1
,2
]}

机构：

[1] Childrens Canc Inst Australia Med Res, Randwick, NSW 2031, Australia

[2] Univ New S Wales, Sydney, NSW 2052, Australia

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 03期

基金：

英国医学研究理事会;

关键词：

III BETA-TUBULIN; CELL LUNG-CANCER; SPINDLE ASSEMBLY CHECKPOINT; METASTATIC BREAST-CANCER; EPOTHILONE-B ANALOG; ANTIMITOTIC DRUGS; OVARIAN-CANCER; IN-VIVO; PACLITAXEL SENSITIVITY; CHILDHOOD LEUKEMIA;

D O I：

10.1038/nrc2803

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Microtubules are dynamic structures composed of alpha-beta-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in beta-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. The aberrant expression of specific beta-tubulin isotypes, in particular beta III-tubulin, or of microtubule-regulating proteins is important clinically in tumour aggressiveness and resistance to chemotherapy. In addition, changes in actin regulation can also mediate resistance to tubulin-binding agents. Understanding the molecular mechanisms that mediate resistance to tubulin-binding agents will be vital to improve the efficacy of these agents.

引用

页码：194 / 204

页数：11

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