Microtubules and resistance to tubulin-binding agents

被引:935
作者
Kavallaris, Maria [1 ,2 ]
机构
[1] Childrens Canc Inst Australia Med Res, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Sydney, NSW 2052, Australia
基金
英国医学研究理事会;
关键词
III BETA-TUBULIN; CELL LUNG-CANCER; SPINDLE ASSEMBLY CHECKPOINT; METASTATIC BREAST-CANCER; EPOTHILONE-B ANALOG; ANTIMITOTIC DRUGS; OVARIAN-CANCER; IN-VIVO; PACLITAXEL SENSITIVITY; CHILDHOOD LEUKEMIA;
D O I
10.1038/nrc2803
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Microtubules are dynamic structures composed of alpha-beta-tubulin heterodimers that are essential in cell division and are important targets for cancer drugs. Mutations in beta-tubulin that affect microtubule polymer mass and/or drug binding are associated with resistance to tubulin-binding agents such as paclitaxel. The aberrant expression of specific beta-tubulin isotypes, in particular beta III-tubulin, or of microtubule-regulating proteins is important clinically in tumour aggressiveness and resistance to chemotherapy. In addition, changes in actin regulation can also mediate resistance to tubulin-binding agents. Understanding the molecular mechanisms that mediate resistance to tubulin-binding agents will be vital to improve the efficacy of these agents.
引用
收藏
页码:194 / 204
页数:11
相关论文
共 116 条
[1]   LIM kinase 2 is widely expressed in all tissues [J].
Acevedo, K ;
Moussi, N ;
Li, R ;
Soo, P ;
Bernard, O .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2006, 54 (05) :487-501
[2]   The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel [J].
Ahmed, Ahmed Ashour ;
Mills, Anthony D. ;
Ibrahim, Ashraf E. K. ;
Temple, Jillian ;
Blenkiron, Cherie ;
Vias, Maria ;
Massie, Charlie E. ;
Iyer, N. Gopalakrishna ;
McGeoch, Adam ;
Crawford, Robin ;
Nicke, Barbara ;
Downward, Julian ;
Swanton, Charles ;
Bell, Stephen D. ;
Earl, Helena M. ;
Laskey, Ronald A. ;
Caldas, Carlos ;
Brenton, James D. .
CANCER CELL, 2007, 12 (06) :514-527
[3]   Loss of Class III β-Tubulin Induced by Histone Deacetylation Is Associated with Chemosensitivity to Paclitaxel in Malignant Melanoma Cells [J].
Akasaka, Kiyomi ;
Maesawa, Chihaya ;
Shibazaki, Masahiko ;
Maeda, Fumihiko ;
Takahashi, Kazuhiro ;
Akasaka, Toshihide ;
Masuda, Tomoyuki .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (06) :1516-1526
[4]   Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells [J].
Alli, Elizabeth ;
Yang, Jin-Ming ;
Ford, James M. ;
Hait, William N. .
MOLECULAR PHARMACOLOGY, 2007, 71 (05) :1233-1240
[5]  
Aoki D, 2009, ANTICANCER RES, V29, P561
[6]   Phase II Genomics Study of Ixabepilone as Neoadjuvant Treatment for Breast Cancer [J].
Baselga, Jose ;
Zambetti, Milvia ;
Llombart-Cussac, Antoni ;
Manikhas, Georgy ;
Kubista, Ernst ;
Steger, Guenther G. ;
Makhson, Anatoly ;
Tjulandin, Sergei ;
Ludwig, Heinz ;
Verrill, Mark ;
Ciruelos, Eva ;
Egyhazi, Suzanne ;
Xu, Li-An ;
Zerba, Kim E. ;
Lee, Hyerim ;
Clark, Edwin ;
Galbraith, Susan .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (04) :526-534
[7]  
Bash-Babula J, 2002, CLIN CANCER RES, V8, P1057
[8]   Stathmin activity influences sarcoma cell shape, motility, and metastatic potential [J].
Belletti, Barbara ;
Nicoloso, Milena S. ;
Schiappacassi, Monica ;
Berton, Stefania ;
Lovat, Francesca ;
Wolf, Katarina ;
Canzonieri, Vincenzo ;
D'Andrea, Sara ;
Zucchetto, Antonella ;
Friedl, Peter ;
Colombatti, Alfonso ;
Baldassarre, Gustavo .
MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (05) :2003-2013
[9]   Lim kinases, regulators of actin dynamics [J].
Bernard, Ora .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (06) :1071-1076
[10]  
Bernard-Marty Chantal, 2002, Clin Breast Cancer, V3, P341, DOI 10.3816/CBC.2002.n.037