Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands

被引:35
作者
Parrill, AL [1 ]
Sardar, VM
Yuan, HB
机构
[1] Memphis State Univ, Dept Chem, Memphis, TN 38152 USA
[2] Memphis State Univ, Computat Res Mat Inst, Memphis, TN 38152 USA
关键词
computational model; lysophosphatidic acid; receptor structure; sphingosine; 1-phosphate; structure activity relationship;
D O I
10.1016/j.semcdb.2004.05.006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Sphingosine 1-phosphate and lysophosphatidic acid are two phospholipid growth factors whose importance in physiology and pathophysiology is becoming more and more apparent. Structure-activity relationships for agonism and antagonism at the thirteen known cell-surface and one intracellular receptor are described. Particular emphasis is placed on ligands having different selectivity than the parent molecules. Structural insights regarding agonist and antagonist recognition by the receptors from both computational modeling studies and crystallography are also discussed. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:467 / 476
页数:10
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