Deltamethrin-induced nuclear erythrocyte alteration and damage to the gills and liver of Colossoma macropomum

被引：26

作者：

Cunha, Fernanda dos Santos ^{[1
]}

Sousa, Natalino da Costa ^{[2
]}

Brandao Santos, Ruda Fernandes ^{[3
]}

Meneses, Juliana Oliveira ^{[1
]}

Silva do Couto, Marcia Valeria ^{[2
]}

Cunha de Almeida, Fabricio Tavares ^{[4
]}

de Sena Filho, Jose Guedes ^{[5
]}

Falanghe Carneiro, Paulo Cesar ^{[5
]}

Maria, Alexandre Nizio ^{[5
]}

Fujimoto, Rodrigo Yudi ^{[5
]}

机构：

[1] Univ Tiradentes, Av Murilo Dantas 300, BR-49032490 Aracaju, SE, Brazil

[2] Fed Univ Para, Alameda Leandro Ribeiro S-N, BR-68600000 Braganca, PA, Brazil

[3] Univ Fed Pernambuco, Enzymol Lab, Dept Biochem, Av Prof Moraes Rego S-N, BR-50670420 Recife, PE, Brazil

[4] Bahia Reg Coll, Av Marechal Candido Rondun S-N, BR-49050680 Aracaju, SE, Brazil

[5] EMBRAPA Tabuleiros Costeiros, Av Beira Mar 3250, BR-49025040 Aracaju, SE, Brazil

来源：

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH | 2018年 / 25卷 / 15期

关键词：

Acute toxicity; Genotoxicity; Histology; Pathology; Pyrethroid; Tambaqui; OXIDATIVE STRESS; ACUTE TOXICITY; PYRETHROID INSECTICIDES; BEHAVIORAL-RESPONSES; MICRONUCLEUS ASSAY; ENZYMATIC-ACTIVITY; GAMBUSIA-AFFINIS; FISH; EXPOSURE; CYPERMETHRIN;

D O I：

10.1007/s11356-018-1622-1

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Deltamethrin is one of the most commonly used pyrethroids in the world, and it has a high toxic potential, mainly on aquatic organism. Thus, the purpose of this study was to evaluate LC50 values of deltamethrin on tambaqui (Colossoma macropomum) fingerlings and to investigate genotoxic effects and histopathological responses. Fish were exposed to different concentrations of deltamethrin (0, 6.16 x 10(-3); 6.44 x 10(-2); 1.34 x 10(-1), and 1.93 x 10(-1) mg L-1) for 96 h. In addition, a genotoxicity analysis was carried out on peripheral blood erythrocytes and histopathological changes were classified by the severity degree of damage and organ functioning. The 96 h LC50 value for tambaqui was estimated at 5.56 x 10(-2) mg L-1 using a static test system. Nuclear abnormalities in exposed fish included micronuclei, blebbed, notched, 8-shaped, and binucleated nuclei forms. Deltamethrin significantly induced a notched nucleus compared to other abnormalities. A histopathological examination showed hepatic lesions and gill damage. Deltamethrin was found to be highly toxic; it induced genotoxicity and caused liver and gill inflammation in tambaqui.

引用

页码：15102 / 15110

页数：9

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