The structural biology of phenazine biosynthesis

被引：93

作者：

Blankenfeldt, Wulf ^{[1
]}

Parsons, James F. ^{[2
]}

机构：

[1] Helmholtz Ctr Infect Res Struct & Funct Prot, D-38124 Braunschweig, Germany

[2] Univ Maryland, Inst Biosci & Biotechnol Res, Rockville, MD 20850 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 29卷

关键词：

PSEUDOMONAS-AERUGINOSA INFECTION; CRYSTAL-STRUCTURE; ANTHRANILATE SYNTHASE; CYSTIC-FIBROSIS; PYOCYANINE BIOSYNTHESIS; METHANOSARCINA-MAZEI; SHIKIMIC ACID; GENE-CLUSTER; PROTEIN PHZF; BACTERIA;

D O I：

10.1016/j.sbi.2014.08.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phenazines are a class of over 150 nitrogen-containing aromatic compounds of bacterial and archeal origin. Their redox properties not only explain their activity as broad-specificity antibiotics and virulence factors but also enable them to function as respiratory pigments, thus extending their importance to the primary metabolism of phenazine-producing species. Despite their discovery in the mid-19th century, the molecular mechanisms behind their biosynthesis have only been unraveled in the last decade. Here, we review the contribution of structural biology that has led to our current understanding of phenazine biosynthesis.

引用

页码：26 / 33

页数：8

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