Update on Merkel Cell Carcinoma

被引：56
作者：
Harms, Paul W. [1 ,2 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pathol, Med Sci 1 3261, 1301 Catherine St, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Dermatol, Med Sci 1 3261, 1301 Catherine St, Ann Arbor, MI 48109 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2017年 / 37卷 / 03期
关键词：
Merkel cell carcinoma; Merkel cell polyomavirus; T antigen; Neuroendocrine carcinoma; Immunotherapy; SMALL T-ANTIGEN; POTENTIAL DIAGNOSTIC PITFALL; IMMUNOHISTOCHEMICAL EXPRESSION; TRABECULAR CARCINOMA; PD-1; BLOCKADE; POLYOMAVIRUS; CYTOKERATIN; TDT; ANTIBODIES; MUTATIONS;
D O I：
10.1016/j.cll.2017.05.004
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine malignancy. Merkel cell polyomavirus, a tumorigenic DNA virus, is present in most MCC tumors, with implications for tumor biology, diagnosis, and management. Merkel cell polyomavirus-negative tumors have a high burden of UV-signature mutations, similar to melanoma. The histopathologic diagnosis of MCC requires immunohistochemistry to exclude morphologically similar entities. Therapies for advanced disease are currently lacking. Here, the features of MCC are reviewed, including recent molecular discoveries with implications for improved therapy for advanced disease.
引用
收藏
页码：485 / +
页数：18
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