Increased circulating erythrocyte-derived microparticles in patients with acute coronary syndromes

被引：3
|
作者：
Liao, Hai-xia [1 ,2 ,3 ]
Meng, Lin-lin [1 ,2 ]
Yu, Xin [1 ,2 ,4 ]
Song, Ming [1 ,2 ]
Shang, Guo-kai [1 ,2 ]
Wang, Di [1 ,2 ]
Wang, Zhi-hao [1 ,2 ,5 ,6 ]
Zhang, Wei [1 ,2 ]
Zhong, Ming [1 ,2 ]
Zhu, Hui [1 ,2 ]
机构：
[1] Chinese Minist Educ, Dept Cardiol, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Natl Hlth Commiss, Jinan, Shandong, Peoples R China
[2] Shandong Univ, State & Shandong Prov Joint Key Lab Translat Card, Qilu Hosp, Cheeloo Coll Med,Chinese Acad Med Sci, Jinan, Shandong, Peoples R China
[3] Beijing Changping Hosp, Dept Cardiol, Beijing, Peoples R China
[4] Peoples Hosp Pingyi Cty, Dept Cardiol, Linyi, Shandong, Peoples R China
[5] Shandong Univ, Dept Geriatr Med, Qilu Hosp, Cheeloo Coll Med, Jinan, Peoples R China
[6] Key Lab Cardiovasc Prote Shandong Prov, Jinan, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 10期
基金：
中国国家自然科学基金;
关键词：
acute coronary syndrome; coronary angiography; coronary artery; erythrocyte-derived microparticles; RED-BLOOD-CELLS; ENDOTHELIAL MICROPARTICLES; PLATELET MICROPARTICLES; MICROVESICLES; THROMBOSIS; ELEVATION; BIOMARKER; RELEASE;
D O I：
10.2217/bmm-2021-0141
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: This study is to explore the predictive value of erythrocyte-derived microparticles (ErMPs) in patients with acute coronary syndrome (ACS). Materials & methods: Total 305 subjects were enrolled and divided into the control group and ACS group. Flow cytometry was used to detect the ErMPs. The Gensini score was calculated based on the results of the coronary angiography. Results: Compared with that in the control group, the ErMPs concentration in the ACS group increased significantly and the concentration of ErMPs was correlated with the ACS risk. The concentration of ErMPs and the percentage of ErMPs were positively correlated with the Gensini score. Conclusion: ErMPs may be a new biomarker for predicting the ACS risk and the coronary artery disease severity.
引用
收藏
页码：741 / 751
页数：11
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