Increased circulating erythrocyte-derived microparticles in patients with acute coronary syndromes

被引：3
|
作者：
Liao, Hai-xia [1 ,2 ,3 ]
Meng, Lin-lin [1 ,2 ]
Yu, Xin [1 ,2 ,4 ]
Song, Ming [1 ,2 ]
Shang, Guo-kai [1 ,2 ]
Wang, Di [1 ,2 ]
Wang, Zhi-hao [1 ,2 ,5 ,6 ]
Zhang, Wei [1 ,2 ]
Zhong, Ming [1 ,2 ]
Zhu, Hui [1 ,2 ]
机构：
[1] Chinese Minist Educ, Dept Cardiol, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Natl Hlth Commiss, Jinan, Shandong, Peoples R China
[2] Shandong Univ, State & Shandong Prov Joint Key Lab Translat Card, Qilu Hosp, Cheeloo Coll Med,Chinese Acad Med Sci, Jinan, Shandong, Peoples R China
[3] Beijing Changping Hosp, Dept Cardiol, Beijing, Peoples R China
[4] Peoples Hosp Pingyi Cty, Dept Cardiol, Linyi, Shandong, Peoples R China
[5] Shandong Univ, Dept Geriatr Med, Qilu Hosp, Cheeloo Coll Med, Jinan, Peoples R China
[6] Key Lab Cardiovasc Prote Shandong Prov, Jinan, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 10期
基金：
中国国家自然科学基金;
关键词：
acute coronary syndrome; coronary angiography; coronary artery; erythrocyte-derived microparticles; RED-BLOOD-CELLS; ENDOTHELIAL MICROPARTICLES; PLATELET MICROPARTICLES; MICROVESICLES; THROMBOSIS; ELEVATION; BIOMARKER; RELEASE;
D O I：
10.2217/bmm-2021-0141
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective: This study is to explore the predictive value of erythrocyte-derived microparticles (ErMPs) in patients with acute coronary syndrome (ACS). Materials & methods: Total 305 subjects were enrolled and divided into the control group and ACS group. Flow cytometry was used to detect the ErMPs. The Gensini score was calculated based on the results of the coronary angiography. Results: Compared with that in the control group, the ErMPs concentration in the ACS group increased significantly and the concentration of ErMPs was correlated with the ACS risk. The concentration of ErMPs and the percentage of ErMPs were positively correlated with the Gensini score. Conclusion: ErMPs may be a new biomarker for predicting the ACS risk and the coronary artery disease severity.
引用
收藏
页码：741 / 751
页数：11
相关论文
共 50 条
  • [11] The acceleration of the propagation phase of thrombin generation in patients with steady-state sickle cell disease is associated with circulating erythrocyte-derived microparticles
    Gerotziafas, Grigoris T.
    Van Dreden, Patrick
    Chaari, Mourad
    Galea, Vassiliki
    Khaterchi, Amir
    Lionnet, Francois
    Stankovic-Stojanovic, Katice
    Blanc-Brude, Olivier
    Woodhams, Barry
    Maier-Redelsperger, Micheline
    Girot, Robert
    Hatmi, Mohamed
    Elalamy, Ismail
    THROMBOSIS AND HAEMOSTASIS, 2012, 107 (06) : 1044 - 1052
  • [12] Platelet interaction with circulating progenitor cells is increased in patients with acute coronary syndromes
    Stellos, K.
    Langer, H.
    Panagiota, V.
    Paul, A.
    Bigalke, B.
    Gawaz, M.
    EUROPEAN HEART JOURNAL, 2010, 31 : 972 - 972
  • [13] Circulating platelet derived microparticles are not increased in patients with cirrhosis
    Rautou, Pierre-Emmanuel
    Vion, Anne-Clemence
    Valla, Dominique
    Boulanger, Chantal M.
    JOURNAL OF HEPATOLOGY, 2013, 59 (04) : 912 - 912
  • [14] Steady State Sickle Cell Anemia Is Associated with Increased Formation of Erythrocyte-Derived Microparticles and Acceleration of Thrombin Generation
    Chaari, Mourad
    Stankovic, Katia
    Galea, Vasso
    Robert, Francoise
    Khaterchi, Amir
    Lionnet, Francois
    Maier, Micheline
    Girot, Robert
    Gerotziafas, Grigorios T.
    Elalamy, Ismail
    BLOOD, 2009, 114 (22) : 1537 - 1537
  • [15] Intracardiac and Peripheral Circulating Endothelial Microparticles Are Increased in Acute Coronary Syndromes and Associated With Central Systolic Blood Pressure
    Vasiliadis, Ioannis E.
    Maurogianni, Aggeliki
    Gavriilaki, Eleni
    Tsaousidis, Adam
    Markala, Dimitra
    Galiagousi, Eugenia
    Douma, Stella
    Zarifis, Ioannis
    CIRCULATION, 2018, 138
  • [16] The Combination of Increased Non-Apoptotic and Decreased Apoptotic Circulating Endothelial Microparticles is Associated With Improved Prognosis in Patients With Acute Coronary Syndromes
    Zacharia, Effimia
    Papageorgiou, Nikolaos
    Antonopoulos, Alexios S.
    Oikonomou, Evangelos
    Pallantza, Zoi
    Miliou, Antigoni
    Kriebardis, Anastasios
    Nikolaos, Orologas
    Valasiadi, Eftychia
    Tousoulis, Dimitrios
    CIRCULATION, 2019, 140
  • [17] Increased platelet binding to circulating monocytes in acute coronary syndromes
    Sarma, J
    Laan, CA
    Alam, S
    Jha, A
    Fox, KAA
    Dransfield, I
    CIRCULATION, 2002, 105 (18) : 2166 - 2171
  • [18] ERYTHROCYTE-DERIVED MICROPARTICLES ACTIVATE PULMONARY ENDOTHELIAL CELLS IN A MURINE MODEL OF TRANSFUSION
    Chang, Alex L.
    Kim, Young
    Seitz, Aaron P.
    Schuster, Rebecca M.
    Lentsch, Alex B.
    Pritts, Timothy A.
    SHOCK, 2017, 47 (05): : 632 - 637
  • [19] The effect of aged erythrocytes and erythrocyte-derived microparticles on lymphomatous and healthy B cells
    Caitlin Hughes
    Mark A Vickers
    Robert N Barker
    Lindsay S Hall
    Journal of Inflammation, 12 (Suppl 1)
  • [20] Reply to: "Circulating platelet derived microparticles are not increased in patients with cirrhosis"
    Tapper, Elliot B.
    Robson, Simon
    Malik, Raza
    JOURNAL OF HEPATOLOGY, 2013, 59 (04) : 913 - 913
12345