Au@Prussian Blue Hybrid Nanomaterial Synergy with a Chemotherapeutic Drug for Tumor Diagnosis and Chemodynamic Therapy

被引：57

作者：

Hang, Lifeng ^{[1
,3
]}

Li, Hailiang ^{[2
]}

Zhang, Tao ^{[3
]}

Men, Dandan ^{[3
]}

Zhang, Cong ^{[3
]}

Gao, Peng ^{[2
]}

Zhang, Qianling ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China

[2] Guangdong Second Prov Gen Hosp, Dept Gen Surg 2, Guangzhou 518037, Guangdong, Peoples R China

[3] Univ Sci & Technol China, Hefei 230027, Anhui, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2019年 / 11卷 / 43期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Fenton reaction; doxorubicin; hydrogen peroxide; hydroxyl radicals; computed tomography imaging; chemo-dynamic therapy; IN-VIVO; MULTIFUNCTIONAL NANOTHERANOSTICS; PHOTODYNAMIC THERAPY; HYDROGEN-PEROXIDE; NANOPARTICLES; CANCER; RESONANCE; DELIVERY; SYSTEMS;

D O I：

10.1021/acsami.9b13470

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Recently, the chemodynamic therapy (CDT) has been widely reported and applied to tumor therapy. However, only low level hydroxyl radicals ((OH)-O-center dot) generated by the endogenous hydrogen peroxide alone are insufficient to kill the cancer cells. To overcome the insufficient therapeutic effect, this study reports a novel CDT based on Fenton catalyst Au@Prussian blue nanocubes (Au@PB NCs), subsequently encapsulated with doxorubicin (Dox). The in vitro and in vivo results indicate that the Dox-Au@PB NCs can take synergistic effects on tumor suppressor by CDT. In addition, Au@PB NCs possess high X-ray computed tomography contrast enhanced efficiency about similar to 27.13 HU.mL.mg(-1). This study highlights a great potential of the Dox-Au@PB NCs for tumor diagnosis and CDT.

引用

页码：39493 / 39502

页数：10

共 53 条

[31] Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy [J].

Li, Zhenglin ;

Hu, Ying ;

Miao, Zhaohua ;

Xu, Han ;

Li, Chunxiao ;

Zhao, Yan ;

Li, Zhuo ;

Chang, Manli ;

Ma, Zhuo ;

Sun, Ye ;

Besenbacher, Flemming ;

Huang, Peng ;

Yu, Miao .

NANO LETTERS, 2018, 18 (11) :6778-6788

[32] A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows [J].

Lin, Han ;

Gao, Shanshan ;

Dai, Chen ;

Chen, Yu ;

Shi, Jianlin .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (45) :16235-16247

[33] Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy [J].

Lin, Li-Sen ;

Huang, Tao ;

Song, Jibin ;

Ou, Xiang-Yu ;

Wang, Zhangtong ;

Deng, Hongzhang ;

Tian, Rui ;

Liu, Yijing ;

Wang, Jun-Feng ;

Liu, Yuan ;

Yu, Guocan ;

Zhou, Zijian ;

Wang, Sheng ;

Niu, Gang ;

Yang, Huang-Hao ;

Chen, Xiaoyuan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (25) :9937-9945

[34] Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy [J].

Lin, Li-Sen ;

Song, Jibin ;

Song, Liang ;

Ke, Kaimei ;

Liu, Yijing ;

Zhou, Zijian ;

Shen, Zheyu ;

Li, Juan ;

Yang, Zhen ;

Tang, Wei ;

Niu, Gang ;

Yang, Huang-Hao ;

Chen, Xiaoyuan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (18) :4902-4906

[35] Black Gold: Plasmonic Colloidosomes with Broadband Absorption Self-Assembled from Monodispersed Gold Nanospheres by Using a Reverse Emulsion System [J].

Liu, Dilong ;

Zhou, Fei ;

Li, Cuncheng ;

Zhang, Tao ;

Zhang, Honghua ;

Cai, Weiping ;

Li, Yue .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (33) :9596-9600

[36] One-Dimensional Fe2P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics [J].

Liu, Yang ;

Zhen, Wenyao ;

Wang, Yinghui ;

Liu, Jianhua ;

Jin, Longhai ;

Zhang, Tianqi ;

Zhang, Songtao ;

Zhao, Ying ;

Song, Shuyan ;

Li, Chengyu ;

Zhu, Junjie ;

Yang, Yang ;

Zhang, Hongjie .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 58 (08) :2407-2412

[37] Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy [J].

Liu, Zhibo ;

Chen, Xiaoyuan .

CHEMICAL SOCIETY REVIEWS, 2016, 45 (05) :1432-1456

[38] A history of exploring cancer in context [J].

Maman, Shelly ;

Witz, Isaac P. .

NATURE REVIEWS CANCER, 2018, 18 (06) :359-376

[39] Nanotheranostics for personalized medicine [J].

Mura, Simona ;

Couvreur, Patrick .

ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (13) :1394-1416

[40] Large-Scale Synthesis of Bioinert Tantalum Oxide Nanoparticles for X-ray Computed Tomography Imaging and Bimodal Image-Guided Sentinel Lymph Node Mapping [J].

Oh, Myoung Hwan ;

Lee, Nohyun ;

Kim, Hyoungsu ;

Park, Seung Pyo ;

Piao, Yuanzhe ;

Lee, Jisoo ;

Jun, Samuel Woojoo ;

Moon, Woo Kyung ;

Choi, Seung Hong ;

Hyeon, Taeghwan .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (14) :5508-5515

← 1 2 3 4 5 6 →