Prevention of Infections During Primary Immunodeficiency

被引：63

作者：

Aguilar, Claire ^{[1
,2
,3
]}

Malphettes, Marion ^{[1
,4
]}

Donadieu, Jean ^{[1
,5
]}

Chandesris, Olivia ^{[1
,3
,6
]}

Coignard-Biehler, Helene ^{[1
,2
,3
]}

Catherinot, Emilie ^{[1
,7
]}

Pellier, Isabelle ^{[1
,8
]}

Stephan, Jean-Louis ^{[1
,9
]}

Le Moing, Vincent ^{[1
,10
]}

Barlogis, Vincent ^{[1
,11
]}

Suarez, Felipe ^{[1
,3
,6
]}

Gerart, Stephane ^{[3
]}

Lanternier, Fanny ^{[1
,2
,3
]}

Jaccard, Arnaud ^{[1
,12
]}

Consigny, Paul-Henri ^{[2
]}

Moulin, Florence ^{[13
]}

Launay, Odile ^{[14
]}

Lecuit, Marc ^{[1
,2
,3
]}

Hermine, Olivier ^{[1
,3
,6
]}

Oksenhendler, Eric ^{[1
,4
]}

Picard, Capucine ^{[1
,3
,15
,16
]}

Blanche, Stephane ^{[1
,3
,16
]}

Fischer, Alain ^{[1
,3
,16
,17
]}

Mahlaoui, Nizar ^{[1
,3
,16
]}

Lortholary, Olivier ^{[1
,2
,3
]}

机构：

[1] Hop Necker Enfants Malad, AP HP, Ctr Reference Deficits Immunitaires Hereditaires, F-75015 Paris, France

[2] Hop Necker Enfants Malad, Ctr Infectiol Necker Pasteur, AP HP, F-75015 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, Inst Hosp Univ IHU Imagine, Paris, France

[4] Hop St Louis, Dept Immunol, St Louis, France

[5] Hop Trousseau, Serv Hematooncol Pediat, Registre Neutropenies Congenitales, Paris, France

[6] Hop Necker Enfants Malad, AP HP, IHU Imagine, Serv Hematol Adulte, Paris, France

[7] Hop Foch, Serv Pneumol, Suresnes, France

[8] Ctr Hosp Univ CHU Angers, Unite Immunohematol Oncol Pediat, Angers, France

[9] CHU St Etienne, Unite Immunohematol Oncol Pediat, St Etienne, France

[10] CHU Montpellier, Serv Malad Infect & Trop, Montpellier, France

[11] Hop La Timone, AP HM, Serv Hematol Pediat, Marseille, France

[12] CHU Dupuytren, Dept Hematol, Limoges, France

[13] Hop Necker Enfants Malad, AP HP, Serv Soins Continus Chirurg, Paris, France

[14] Univ Paris 05, Sorbonne Paris Cite, CIC Vaccinol Cochin Pasteur, Paris, France

[15] Hop Necker Enfants Malad, AP HP, Ctr Etude Deficits Immunitaires Primitifs, Paris, France

[16] Hop Necker Enfants Malad, Unite Immunol & Hematol Pediat, IHU Imagine, Paris, France

[17] Coll France, F-75231 Paris, France

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 59卷 / 10期

关键词：

prophylaxis; primary immunodeficiency; immunizations; immunoglobulins; CHRONIC GRANULOMATOUS-DISEASE; TRIMETHOPRIM-SULFAMETHOXAZOLE; CLINICAL-FEATURES; MANAGEMENT; PROPHYLAXIS; DIAGNOSIS; DEFICIENCIES; RECOMBINANT; BACTERIAL; EFFICACY;

D O I：

10.1093/cid/ciu646

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Because infectious diseases are a major source of morbidity and mortality in the majority of patients with primary immunodeficiencies (PIDs), the application of a prophylactic regimen is often necessary. However, because of the variety of PIDs and pathogens involved, and because evidence is scarce, practices are heterogeneous. To homogenize practices among centers, the French National Reference Center for PIDs aimed at elaborating recommendations for anti-infectious prophylaxis for the most common PIDs. We performed a literature review of infectious complications and prophylactic regimens associated with the most frequent PIDs. Then, a working group including different specialists systematically debated about chemoprophylaxis, immunotherapy, immunization, and recommendations for patients. Grading of prophylaxis was done using strength of recommendations (decreasing from A to D) and evidence level (decreasing from I to III). These might help infectious diseases specialists in the management of PIDs and improving the outcome of patients with PIDs.

引用

页码：1462 / 1470

页数：9

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