Function and regulation of Aurora/Ipl1p kinase family in cell division

被引：60
作者：
Ke, YW
Dou, Z
Zhang, J
Yao, XB [1 ]
机构：
[1] Univ Sci & Technol China, Lab Cell Dynam, Sch Life Sci, Hefei 230027, Peoples R China
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
CELL RESEARCH | 2003年 / 13卷 / 02期
关键词：
Aurora (Ipl1p); mitosis and cancer;
D O I：
10.1038/sj.cr.7290152
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis, of human cancer.
引用
收藏
页码：69 / 81
页数：13
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