Application of Genome-Wide Association Studies in Coronary Artery Disease

被引：4

作者：

Zheng, Huilei ^{[1
,2
,3
]}

Zeng, Zhiyu ^{[2
,3
,4
]}

Wen, Hong ^{[2
,3
,5
]}

Wang, Peng ^{[1
]}

Huang, Chunxia ^{[1
]}

Huang, Ping ^{[1
]}

Chen, Qingyun ^{[1
]}

Gong, Danping ^{[2
,3
,4
]}

Qiu, Xiaoling ^{[2
,3
,6
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Med Examinat & Hlth Management, Nanning, Guangxi, Peoples R China

[2] Guangxi Key Lab Precis Med Cardiocerebrovasc Dis, Nanning, Guangxi, Peoples R China

[3] Guangxi Clin Res Ctr Cardiocerebrovasc Dis, Nanning, Guangxi, Peoples R China

[4] Guangxi Med Univ, Affiliated Hosp 1, Elderly Cardiol Ward, Nanning, Guangxi, Peoples R China

[5] Guangxi Med Univ, Affiliated Hosp 1, Elderly Comprehens Ward, Nanning, Guangxi, Peoples R China

[6] Duke Univ, Sch Med, Dept Populat Hlth Sci, Durham, NC 27708 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 40期

关键词：

Genome-wide association study; coronary artery disease; genetic susceptibility locus; single nucleotide polymorphism; genetic factors; genetic mechanism; APOLIPOPROTEIN A5 GENE; ISCHEMIC-HEART-DISEASE; ATP-BINDING CASSETTE; FACTOR-ALPHA GENE; MYOCARDIAL-INFARCTION; INCREASED RISK; CARDIOVASCULAR-DISEASE; INSERTION/DELETION POLYMORPHISM; PROMOTER POLYMORPHISM; UPDATED METAANALYSIS;

D O I：

10.2174/1381612825666191105125148

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coronary artery disease (CAD) is a complex disease caused by the combination of environmental and genetic factors. It is one of the leading causes of death and disability in the world. Much research has been focussed on CAD genetic mechanism. In recent years, genome-wide association study (GWAS) has developed rapidly around the world. Medical researchers around the world have successfully discovered a series of CAD genetic susceptibility genes or susceptible loci using medical research strategies, leading CAD research toward a new stage. This paper briefly summarizes the important progress made by GWAS for CAD in the world in recent years, and then analyzes the challenges faced by GWAS at this stage and the development trend of future research, to promote the transformation of genetic research results into clinical practice and provide guidance for further exploration of the genetic mechanism of CAD.

引用

页码：4274 / 4286

页数：13

共 139 条

[81] Inherited apolipoprotein A-V deficiency in severe hypertriglyceridemia [J].