Application of Genome-Wide Association Studies in Coronary Artery Disease

被引：4

作者：

Zheng, Huilei ^{[1
,2
,3
]}

Zeng, Zhiyu ^{[2
,3
,4
]}

Wen, Hong ^{[2
,3
,5
]}

Wang, Peng ^{[1
]}

Huang, Chunxia ^{[1
]}

Huang, Ping ^{[1
]}

Chen, Qingyun ^{[1
]}

Gong, Danping ^{[2
,3
,4
]}

Qiu, Xiaoling ^{[2
,3
,6
]}

机构：

[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Med Examinat & Hlth Management, Nanning, Guangxi, Peoples R China

[2] Guangxi Key Lab Precis Med Cardiocerebrovasc Dis, Nanning, Guangxi, Peoples R China

[3] Guangxi Clin Res Ctr Cardiocerebrovasc Dis, Nanning, Guangxi, Peoples R China

[4] Guangxi Med Univ, Affiliated Hosp 1, Elderly Cardiol Ward, Nanning, Guangxi, Peoples R China

[5] Guangxi Med Univ, Affiliated Hosp 1, Elderly Comprehens Ward, Nanning, Guangxi, Peoples R China

[6] Duke Univ, Sch Med, Dept Populat Hlth Sci, Durham, NC 27708 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 40期

关键词：

Genome-wide association study; coronary artery disease; genetic susceptibility locus; single nucleotide polymorphism; genetic factors; genetic mechanism; APOLIPOPROTEIN A5 GENE; ISCHEMIC-HEART-DISEASE; ATP-BINDING CASSETTE; FACTOR-ALPHA GENE; MYOCARDIAL-INFARCTION; INCREASED RISK; CARDIOVASCULAR-DISEASE; INSERTION/DELETION POLYMORPHISM; PROMOTER POLYMORPHISM; UPDATED METAANALYSIS;

D O I：

10.2174/1381612825666191105125148

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coronary artery disease (CAD) is a complex disease caused by the combination of environmental and genetic factors. It is one of the leading causes of death and disability in the world. Much research has been focussed on CAD genetic mechanism. In recent years, genome-wide association study (GWAS) has developed rapidly around the world. Medical researchers around the world have successfully discovered a series of CAD genetic susceptibility genes or susceptible loci using medical research strategies, leading CAD research toward a new stage. This paper briefly summarizes the important progress made by GWAS for CAD in the world in recent years, and then analyzes the challenges faced by GWAS at this stage and the development trend of future research, to promote the transformation of genetic research results into clinical practice and provide guidance for further exploration of the genetic mechanism of CAD.

引用

页码：4274 / 4286

页数：13

共 139 条

[51] Resequencing and Clinical Associations of the 9p21.3 Region A Comprehensive Investigation in the Framingham Heart Study [J].

Johnson, Andrew D. ;

Hwang, Shih-Jen ;

Voorman, Arend ;

Morrison, Alanna ;

Peloso, Gina M. ;

Hsu, Yi-Hsiang ;

Thanassoulis, George ;

Newton-Cheh, Christopher ;

Rogers, Ian S. ;

Hoffmann, Udo ;

Freedman, Jane E. ;

Fox, Caroline S. ;

Psaty, Bruce M. ;

Boerwinkle, Eric ;

Cupples, L. Adrienne ;

O'Donnell, Christopher J. .

CIRCULATION, 2013, 127 (07) :799-810

[52] A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia [J].

Kao, JT ;

Wen, HC ;

Chien, KL ;

Hsu, HC ;

Lin, SW .

HUMAN MOLECULAR GENETICS, 2003, 12 (19) :2533-2539

[53] A PCSK9 missense variant associated with a reduced risk of early-onset myocardial infarction [J].

Kathiresan, Sekar .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (21) :2299-2300

[54] Association of Apolipoprotein A5 Gene Polymorphisms with Metabolic Syndrome in the Korean Population [J].

Kim, Young Ree ;

Hong, Seung-Ho .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2016, 20 (03) :130-136

[55] Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease [J].

Klarin, Derek ;

Zhu, Qiuyu Martin ;

Emdin, Connor A. ;

Chaffin, Mark ;

Horner, Steven ;

McMillan, Brian J. ;

Leed, Alison ;

Weale, Michael E. ;

Spencer, Chris C. A. ;

Aguet, Francois ;

Segre, Ayellet V. ;

Ardlie, Kristin G. ;

Khera, Amit V. ;

Kaushik, Virendar K. ;

Natarajan, Pradeep ;

Kathiresan, Sekar .

NATURE GENETICS, 2017, 49 (09) :1392-+

[56] The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore [J].

Lai, CQ ;

Tai, ES ;

Tan, CE ;

Cutter, J ;

Chew, SK ;

Zhu, YP ;

Adiconis, X ;

Ordovas, JM .

JOURNAL OF LIPID RESEARCH, 2003, 44 (12) :2365-2373

[57]

Li Hongyu, 2018, Front Biosci (Schol Ed), V10, P185

[58]

Li Jie, 2007, Zhonghua Yixue Yichuanxue Zazhi, V24, P576

[59] Polymorphisms of the LTA Gene May Contribute to the Risk of Myocardial Infarction: A Meta-Analysis [J].

Li, Na ;

Liu, Runmei ;

Zhai, Hongxia ;

Li, Liang ;

Yin, Yaxin ;

Zhang, Jinjin ;

Xia, Yunfeng .

PLOS ONE, 2014, 9 (03)

[60] ApoB gene SpIns/Del, XbaI polymorphisms and myocardial infarction: a meta-analysis of 7169 participants [J].

Li, Yan-yan .

JOURNAL OF CARDIOVASCULAR MEDICINE, 2014, 15 (09) :717-726

← 1 2 3 4 5 6 7 8 9 10 →