A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms

被引：23

作者：

Ma, Dik-Lung ^{[1
]}

Wang, Wanhe ^{[1
]}

Mao, Zhifeng ^{[1
]}

Yang, Chao ^{[2
]}

Chen, Xiu-Ping ^{[2
]}

Lu, Jin-Jian ^{[2
]}

Han, Quan-Bin ^{[3
]}

Leung, Chung-Hang ^{[2
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[3] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China

来源：

ANALYTICA CHIMICA ACTA | 2016年 / 913卷

基金：

中国国家自然科学基金;

关键词：

Oligonucleotide-based sensor; G-quadruplex; Enzyme; Sensor construction; T4 POLYNUCLEOTIDE KINASE; ROLLING-CIRCLE AMPLIFICATION; LABEL-FREE DETECTION; SWITCH-ON DETECTION; ULTRASENSITIVE ELECTROCHEMICAL DETECTION; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE; ASSISTED SIGNAL AMPLIFICATION; COLORIMETRIC DNA DETECTION; NUCLEIC-ACID APTAMERS; SPLIT G-QUADRUPLEX;

D O I：

10.1016/j.aca.2016.01.043

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

With rapid advances in the field of DNA chemistry, nucleic acids and DNA-modifying enzymes have recently emerged as versatile components for the construction of oligonucleotide-based sensors. Meanwhile, the G-quadruplex motif has been widely employed for the development of DNA-based assays due to its diverse structural variety. In this tutorial, we introduce the principles of G-quadruplex-based sensing and the use of DNA-modifying enzymes for sensor platform development. We also highlight recent studies of the application of DNA-modifying enzymes for the development of G-quadruplex-based luminescent detection platforms with a view towards how those enzymes play an important role in sensitivity enhancement. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：41 / 54

页数：14

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