RADIATION DOSE-VOLUME EFFECTS IN THE HEART

被引：507
作者：
Gagliardi, Giovanna [1 ,2 ]
Constine, Louis S. [3 ]
Moiseenko, Vitali [4 ]
Correa, Candace [5 ]
Pierce, Lori J. [5 ]
Allen, Aaron M. [6 ,7 ]
Marks, Lawrence B. [8 ]
机构：
[1] Karolinska Univ Hosp, Dept Med Phys, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Stockholm, Sweden
[3] Univ Rochester, Ctr Canc, Dept Radiat Oncol, Rochester, NY 14642 USA
[4] British Columbia Canc Agcy, Vancouver Canc Ctr, Vancouver, BC V5Z 4E6, Canada
[5] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
[6] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
[7] Rabin Med Ctr Petach Tikvah, Petah Tiqwa, Israel
[8] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC USA
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2010年 / 76卷 / 03期
关键词：
Radiation heart disease; Dose-volume predictors; NTCP; Breast cancer; Lymphoma; Esophagus cancer; BREAST-CANCER PATIENTS; TERM CARDIAC MORTALITY; CORONARY-ARTERY-DISEASE; HODGKINS-DISEASE; POSTOPERATIVE RADIOTHERAPY; CARDIOVASCULAR-DISEASE; RISK-FACTORS; THERAPY; IRRADIATION; CARDIOTOXICITY;
D O I：
10.1016/j.ijrobp.2009.04.093
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity h as not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury. (C) 2010 Elsevier Inc.
引用
收藏
页码：S77 / S85
页数：9
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