Specific Features of TLR4 Expression in Structural Elements of Placenta in Patients with Preeclampsia

被引：15

作者：

Kulikova, G. V. ^{[1
]}

Nizyaeva, N. V. ^{[1
]}

Nagovitsina, M. N. ^{[1
]}

Lyapin, V. M. ^{[1
]}

Loginova, N. S. ^{[1
]}

Kan, N. E. ^{[1
]}

Tyutyunnik, V. L. ^{[1
]}

Tyutyunnik, N. V. ^{[1
]}

Schegolev, A. I. ^{[1
]}

机构：

[1] VI Kulakov Res Ctr Obstet Gynecol & Perinatol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 05期

关键词：

preeclampsia; placenta; trophoblast; interstitial pacemaker cells; Toll-like receptors; INTERSTITIAL-CELLS;

D O I：

10.1007/s10517-016-3259-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the expression of TLR4 (Toll-like receptor 4) in the syncytiotrophoblast and vascular endothelial cells of terminal and stem placental villi in severe preeclampsia and normal pregnancy. In women of both groups, the expression of TLR4 was higher in the syncytiotrophoblast that in placental endothelial cells. In patients with severe preeclampsia, TLR4 expression in endothelial cells of terminal villi was 1.3-fold lower than in normal pregnancy. Lower TLR4 expression in the terminal villi endothelium in preeclampsia can underlie impaired recognition of damaging molecules with subsequent development of endothelial dysfunction and changes in immunological tolerance.

引用

页码：718 / 721

页数：4

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