Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies

被引:25
作者
Haghshomar, Maryam [1 ]
Dolatshahi, Mahsa [1 ]
Sherbaf, Farzaneh Ghazi [1 ]
Moghaddam, Hossein Sanjari [1 ]
Shandiz, Mehdi Shirin [2 ]
Aarabi, Mohammad Hadi [1 ]
机构
[1] Univ Tehran Med Sci, Fac Med, Tehran, Iran
[2] Zahedan Univ Med Sci, Dept Med Phys, Zahedan, Iran
来源
FRONTIERS IN NEUROLOGY | 2018年 / 9卷
关键词
diffusion tensor imaging (DTI); inferior longitudinal fasciculus (ILF); Parkinson's disease white matter; microstructure; fractional anisotropy (FA); mean diffusivity (MD); SLEEP BEHAVIOR DISORDER; MILD COGNITIVE IMPAIRMENT; WHITE-MATTER INTEGRITY; FUNCTIONAL CONNECTIVITY; REM-SLEEP; STRUCTURAL CONNECTIVITY; OLFACTORY DYSFUNCTION; SPATIAL STATISTICS; TEMPORAL CORTEX; ALPHA-SYNUCLEIN;
D O I
10.3389/fneur.2018.00598
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms. One of the white matter tracts shown to be disrupted in PD with a possible contribution to some PD symptoms is the inferior longitudinal fasciculus (ILF). On the whole, lower ILF integrity contributes to thought disorders, impaired visual emotions, cognitive impairments such as semantic fluency deficits, and mood disorders. This review outlines the microstructural changes in ILF associated with systemic inflammation and various PD symptoms like cognitive decline, facial emotion recognition deficit, depression, color discrimination deficit, olfactory dysfunction, and tremor genesis. However, few studies have investigated DTI correlates of each symptom and larger studies with standardized imaging protocols are required to extend these preliminary findings and lead to more promising results.
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页数:18
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